Items where Author, Editor or other role is "Smales, Mark"

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Number of items: 139.

A

Alrobaish, Shouaa A (2019) Characterisation of the Fucose and Rhamnose Utilising Bacterial Microcompartment system in Clostridium phytofermentans. Doctor of Philosophy (PhD) thesis, University of Kent,. (KAR id:77738)

AJAYI, FOLASADE ABIOSE (2019) Reprogramming of Sterol Biosynthesis in Chinese Hamster Ovary Cells for Enhanced Recombinant Protein Production. Doctor of Philosophy (PhD) thesis, University of Kent,. (KAR id:79941)

Almeida, Aline G., Pinto, Rodrigo C. V., Smales, Christopher Mark, Castilho, Leda R. (2017) Investigations into, and development of, a lyophilized and formulated recombinant human factor IX produced from CHO cells. Biotechnology Letters, 39 (8). pp. 1109-1120. ISSN 0141-5492. E-ISSN 1573-6776. (doi:10.1007/s10529-017-2353-y) (KAR id:61688)

Ashton, Lorna, Hogwood, Catherine E.M., Tait, Andrew S., Kuligowski, Julia, Smales, Christopher Mark, Bracewell, Daniel G., Dickson, Alan J., Goodacre, Royston (2014) UV resonance Raman spectroscopy: a process analytical tool for host cell DNA and RNA dynamics in mammalian cell lines. Journal of Chemical Technology and Biotechnology, 90 (2). pp. 237-243. ISSN 0268-2575. (doi:10.1002/jctb.4420) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:52457)

Al-Fageeh, Mohamed B., Smales, Christopher Mark (2013) Alternative Promoters Regulate Cold Inducible RNA-Binding (CIRP) Gene Expression and Enhance Transgene Expression in Mammalian Cells. Molecular Biotechnology, 54 (2). pp. 238-249. ISSN 1073-6085. (doi:10.1007/s12033-013-9649-5) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:33895)

Al-Fageeh, Mohamed B., Smales, Christopher Mark (2009) Cold-inducible RNA binding protein (CIRP) expression is modulated by alternative mRNAs. RNA, 15 (6). pp. 1164-1176. ISSN 1355-8382. (doi:10.1261/rna.1179109) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:31418)

Ahmad, Norhaiza, Zhang, Jian, Brown, Philip J., James, David C., Birch, John R., Racher, Andrew J., Smales, Christopher Mark (2006) On the statistical analysis of the GS-NS0 cell proteome: Imputation, clustering and variability testing. Biochimica Et Biophysica Acta-Proteins and Proteomics, 1764 (7). pp. 1179-1187. ISSN 1570-9639. (doi:10.1016/j.bbapap.2006.05.002) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6224)

Al-Fageeh, Mohamed B., Marchant, Rosalyn J., Carden, Martin J., Smales, Christopher Mark (2006) The cold-shock response in cultured mammalian cells: Harnessing the response for the improvement of recombinant protein production. Biotechnology and Bioengineering, 93 (5). pp. 829-835. ISSN 0006-3592. (doi:10.1002/bit.20789) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6229)

Al-Fageeh, Mohamed B., Smales, Christopher Mark (2006) Control and regulation of the cellular responses to cold shock: the responses in yeast and mammalian systems. Biochemical Journal, 397 . pp. 247-259. ISSN 0264-6021. (doi:10.1042/BJ20060166) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6225)

Alete, Daniel E., Racher, Andrew J., Birch, John R., Stansfield, Scott H., James, David C., Smales, Christopher Mark (2005) Proteomic analysis of enriched microsomal fractions from GS-NS0 murine myeloma cells with varying secreted recombinant monoclonal antibody productivities. Proteomics, 5 (18). pp. 4689-4704. ISSN 1615-9853. (doi:10.1002/pmic.200500019) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6218)

Alete, Daniel E. and Racher, R.J. and Birch, John R. and James, David C. and Smales, Christopher Mark (2005) The functional competence of animal cells: Analysis of the secretory pathway. In: Godia, Francesc and Fussenegger, Martin M., eds. Animal Cell Technology Meets Genomics. ESACT Proceedings, 2 . Springer, Dordrecht, pp. 71-74. ISBN 978-1-4020-2791-8. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6222)

B

Beal, David M, Liang, Mingzhi, Brown, Ian R., Budge, James D., Burrows, Emily R., Howland, Kevin, Lee, Phoebe, Martin, Sarah, Morrell, Andrew, Nemoto-Smith, Emi, and others. (2023) Modification of bacterial microcompartments with target biomolecules via post-translational SpyTagging. Materials Advances, 4 (14). pp. 2963-2970. E-ISSN 2633-5409. (doi:10.1039/d3ma00071k) (KAR id:101867)

Bledowski, Nicole (2022) Development of Reporter Systems of Cellular Readouts of Chinese Hamster Ovary (CHO) Cells. Master of Science by Research (MScRes) thesis, University of Kent,. (doi:10.22024/UniKent/01.02.98518) (KAR id:98518)

Burrows, Emily (2022) Generation of SARS-CoV-2 Coronavirus Protein Antigens for Development of Diagnostics and Novel Vaccine Approaches. Master of Science by Research (MScRes) thesis, University of Kent. (doi:10.22024/UniKent/01.02.93185) (KAR id:93185)

Bracewell, Daniel G., Smith, Victoria, Delahaye, Mike, Smales, Christopher Mark (2021) Analytics of Host Cell Proteins (HCPs): Lessons from Biopharmaceutical mAb Analysis for Gene Therapy Products. Current Opinion in Biotechnology, 71 . pp. 98-104. ISSN 0958-1669. (doi:10.1016/j.copbio.2021.06.026) (KAR id:89635)

Budge, James D., Roobol, Joanne, Singh, Gurdeep, Mozzanino, Théo, Knight, Tanya J., Povey, Jane F., Dean, Andrew, Turner, Sarah J, Jaques, Colin M., Young, Robert J., and others. (2021) A proline metabolism selection system and its application to the engineering of lipid biosynthesis in Chinese hamster ovary cells. Metabolic Engineering Communications, 13 . Article Number e00179. ISSN 2214-0301. (doi:10.1016/j.mec.2021.e00179) (KAR id:89636)

Budge, James D, Young, Robert J, Smales, Christopher Mark (2021) Engineering of Chinese Hamster Ovary Cells With NDPK-A to Enhance DNA Nuclear Delivery Combined With EBNA1 Plasmid Maintenance Gives Improved Exogenous Transient Reporter, mAb and SARS-CoV-2 Spike Protein Expression. Frontiers in Bioengineering and Biotechnology, 9 . Article Number 679448. ISSN 2296-4185. (doi:10.3389/fbioe.2021.679448) (KAR id:89633)

Budge, James D., Knight, Tanya J., Povey, Jane, Roobol, Joanne, Brown, Ian R., Singh, Gurdeep, Dean, Andrew, Turner, Sarah, Jaques, Colin M., Young, Robert J., and others. (2020) Data for engineering lipid metabolism of Chinese hamster ovary (CHO) cells for enhanced recombinant protein production. Data in Brief, 29 . p. 105217. ISSN 2352-3409. (doi:10.1016/j.dib.2020.105217) (KAR id:80444)

Budge, James D., Knight, Tanya, Povey, Jane F., Roobol, Joanne, Brown, Ian R., Singh, Gurdeep, Dean, Andrew, Turner, Sarah, Jaques, Colin M., Young, Robert J., and others. (2019) Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production. Metabolic Engineering, 57 . pp. 203-216. ISSN 1096-7176. (doi:10.1016/j.ymben.2019.11.007) (KAR id:79466)

Binge, Alexandra (2018) Development of Endogenous and Synthetic CHO Promoter Expression Systems for Recombinant Protein Production. Doctor of Philosophy (PhD) thesis, University of Kent,. (doi:10.22024/UniKent/01.02.66640) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:66640)

Lonza Ltd (2017) Modulation of lipid metabolism for protein production. WO2017191165A1. (doi:WO2017191165A1) (KAR id:85781)

Bastide, Amandine, Peretti, Diego, Knight, John R.P., Grosso, Stefano, Spriggs, Ruth V., Pichon, Xavier, Sbarrato, Thomas, Roobol, Anne, Roobol, Jo, Vito, Davide, and others. (2017) RTN3 Is a Novel Cold-Induced Protein and Mediates Neuroprotective Effects of RBM3. Current Biology, 27 (5). pp. 638-650. ISSN 0960-9822. (doi:10.1016/j.cub.2017.01.047) (KAR id:60753)

Bracewell, Daniel G., Francis, Richard, Smales, Christopher Mark (2015) The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control. Biotechnology and Bioengineering, 112 (9). pp. 1727-1737. ISSN 0006-3592. (doi:10.1002/bit.25628) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:50203)

Bracewell, Daniel G., Smales, Christopher Mark (2013) The challenges of product- and process-related impurities to an evolving biopharmaceutical industry. Bioanalysis, 5 (2). pp. 123-126. ISSN 1757-6180. (doi:10.4155/bio.12.314) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:33131)

C

Chengan, Kameshwari, Hind, Charlotte, Stanley, Maria, Wand, Matthew E., Nagappa, Lakshmeesha K., Howland, Kevin, Hanson, Tanith, Martín-Escolano, Rubén, Tsaousis, Anastasios D., Bengoechea, José A., and others. (2023) A cell-free strategy for host-specific profiling of intracellular antibiotic sensitivity and resistance. npj Antimicrobials and Resistance, 1 (1). Article Number 16. ISSN 2731-8745. (doi:10.1038/s44259-023-00018-z) (KAR id:104336)

Chiverton, Lesley M., Evans, Caroline, Pandhal, Jagroop, Landels, Andrew R., Rees, Byron J., Levison, Peter R., Wright, Phillip C., Smales, Christopher Mark (2016) Quantitative definition and monitoring of the host cell protein proteome using iTRAQ: a study of an industrial mAb producing CHO-S cell line. Biotechnology Journal, 11 (8). pp. 1014-1024. ISSN 1860-6768. (doi:10.1002/biot.201500550) (KAR id:56829)

Creigh-Pulatmen, Tilbe (2014) Structural and functional characterisation of the cold-inducible RNA-binding protein CIRP and its application to enhanced recombinant protein production. Doctor of Philosophy (PhD) thesis, University of Kent,. (KAR id:47913)

Cooke, D.G., Flight, S., Smales, Christopher Mark, Blackwell, Leonard F. (2003) Use of defined estrone glucuronide-hen egg white lysozyme conjugates as signal generators in homogeneous enzyme immunoassays for urinary estrone glucuronide. Journal of Immunoassay & Immunochemistry, 24 (2). pp. 147-172. ISSN 1532-1819. (doi:10.1081/IAS-120020082) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6214)

D

Dyball, Laura E, Smales, C. Mark (2022) Exosomes: Biogenesis, targeting, characterization and their potential as "Plug & Play" vaccine platforms. Biotechnology Journal, 17 (11). Article Number 2100646. ISSN 1860-7314. (doi:10.1002/biot.202100646) (KAR id:98036)

Deimantaviciute, Gintare (2022) Producing intracellular and extracellular lipid vesicles in E. coli for vaccine development. Doctor of Philosophy (PhD) thesis, University of Kent,. (doi:10.22024/UniKent/01.02.93714) (KAR id:93714)

De Poi, Stuart P, Xie, Jianling, Smales, Christopher Mark, Proud, Christopher G (2021) Constitutively-active Rheb mutants [T23M] and [E40K] drive increased production and secretion of recombinant protein in Chinese hamster ovary cells. Biotechnology and Bioengineering, 118 (7). pp. 2422-2434. ISSN 0006-3592. (doi:10.1002/bit.27748) (KAR id:89632)

Davies, Stephanie Ann (2014) Determination of Bioprocessing Variables that Influence Particle and Aggregation Formation of Therapeutic IgGs. Doctor of Philosophy (PhD) thesis, University of Kent,. (doi:10.22024/UniKent/01.02.48573) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:48573)

Dean, Andrew (2014) Investigating the Restraints Upon Recombinant Protein Production in Mammalian Cells via the Manipulation of eEF2, eEF2K and mTOR. Doctor of Philosophy (PhD) thesis, University of Kent,. (KAR id:47962)

Dinnis, Diane M., Stansfield, Scott H., Schlatter, Stefan, Smales, Christopher Mark, Alete, Daniel E., Birch, John R., Racher, Andrew J., Marshal, Carol T., Nielsen, Lars K., James, David C. and others. (2006) Functional proteomic analysis of GS-NS0 murine myeloma cell lines with varying recombinant monoclonal antibody production rate. Biotechnology and Bioengineering, 94 (5). pp. 830-841. ISSN 0006-3592. (doi:10.1002/bit.20899) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6226)

Davis, Paul J., Smales, Christopher Mark, James, David C. (2001) How can Thermal Processing Modify the Antigenicity of Proteins? Allergy, 56 (s67). pp. 56-60. ISSN 0105-4538. (doi:10.1034/j.1398-9995.2001.00918.x) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6209)

F

Feary, M., Racher, A.J., Young, R.J., Smales, Christopher Mark (2016) Methionine sulfoximine supplementation enhances productivity in GS-CHOK1SV cell lines through glutathione biosynthesis. Biotechnology Progress, 33 (1). pp. 17-25. ISSN 8756-7938. E-ISSN 1520-6033. (doi:10.1002/btpr.2372) (KAR id:60241)

G

Gourbatsi, Evdoxia, Povey, Jane F., Smales, Christopher Mark (2018) The effect of formulation variables on protein stability and integrity of a model IgG4 monoclonal antibody and translation to formulation of a model ScFv. Biotechnology Letters, 40 (1). pp. 33-46. ISSN 0141-5492. E-ISSN 1573-6776. (doi:10.1007/s10529-017-2443-x) (KAR id:63854)

Godfrey, Charlotte (2017) Investigation of Translational Reprogramming during Transient and Stable Expression of Monoclonal Antibodies in Chinese Hamster Ovary Cells. Doctor of Philosophy (PhD) thesis, University of Kent,. (doi:10.22024/UniKent/01.02.65774) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:65774)

Godfrey, Charlotte, Mead, Emma J, Daramola, Olalekan, Dunn, Sarah, Hatton, Diane, Field, Ray, Pettman, Gary, Smales, Christopher Mark (2017) Polysome Profiling of mAb Producing CHO Cell Lines Links Translational Control of Cell Proliferation and Recombinant mRNA Loading onto Ribosomes with Global and Recombinant Protein Synthesis. Biotechnology Journal, 12 (8). Article Number 1700177. ISSN 1860-6768. E-ISSN 1860-7314. (doi:10.1002/biot.201700177) (KAR id:61820)

Gourbatsi, Evdoxia, Povey, Jane F., Uddin, Shahid, Smales, Christopher Mark (2016) Biotherapeutic protein formulation variables influence protein integrity and can promote post-translational modifications as shown using chicken egg white lysozyme as a model system. Biotechnology Letters, 38 (4). pp. 589-596. ISSN 0141-5492. E-ISSN 1573-6776. (doi:10.1007/s10529-015-2014-y) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:54863)

Gourbatsi, Evdoxia, Al-Fageeh, Mohamed B., Marchant, Rosalyn J., Scott, Sarah J., Underhill, Michele F., Smales, Christopher Mark (2006) Noncovalently linked nuclear localization peptides for enhanced calcium phosphate transfection. Molecular Biotechnology, 33 (1). pp. 1-11. ISSN 1073-6085. (doi:10.1385/MB:33:1:1) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6228)

H

Hedayioglu, Fabio, Mead, Emma J, O'Connor, Patrick B F, Skiotys, Matas, Sansom, Owen J, Mallucci, Giovanna R, Willis, Anne E, Baranov, Pavel V, Smales, Christopher Mark, von der Haar, Tobias and others. (2022) Evaluating data integrity in ribosome footprinting datasets through modelled polysome profiles. Nucleic Acids Research, 50 (19). Article Number e112. ISSN 1362-4962. (doi:10.1093/nar/gkac705) (KAR id:98090)

Hussain, Hirra, Patel, Tulshi, Ozanne, Angelica M.S., Vito, Davide, Ellis, Mark, Hinchliffe, Matthew, Humphreys, David P., Stephens, Paul E., Sweeney, Bernie, White, James, and others. (2021) A comparative analysis of recombinant Fab and full‐length antibody production in Chinese hamster ovary cells. Biotechnology and Bioengineering, 118 (12). pp. 4815-4828. ISSN 1097-0290. (doi:10.1002/bit.27944) (KAR id:102666)

Hutton, Rachael (2015) Investigating the Role of TOR Signalling, and the Link between Actin Binding Protein Cofilin and Mitochondrial Function and their Effects on Recombinant Protein Production. Doctor of Philosophy (PhD) thesis, University of Kent. (KAR id:54751)

Hogwood, Catherine E.M., Ahmad, Shahina S., Tarrant, Richard D., Bracewell, Daniel G., Smales, Christopher Mark (2015) An ultra scale-down approach identifies host cell protein differences across a panel of mAb producing CHO cell line variants. Biotechnology Journal, 11 (3). pp. 415-424. ISSN 1860-6768. E-ISSN 1860-7314. (doi:10.1002/biot.201500010) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:54880)

Hogwood, Catherine EM, Bracewell, Daniel G, Smales, Christopher Mark (2014) Measurement and control of host cell proteins (HCPs) in CHO cell bioprocesses. Current Opinion in Biotechnology, 30 . pp. 153-160. ISSN 0958-1669. (doi:10.1016/j.copbio.2014.06.017) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:42023)

Hogwood, Catherine EM, Bracewell, Daniel G, Smales, Christopher Mark (2013) Host cell protein dynamics in recombinant CHO cells. Bioengineered, 4 (5). pp. 288-291. ISSN 2165-5979. (doi:10.4161/bioe.23382) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:61211)

Hogwood, Catherine E.M., Tait, Andrew S., Koloteva-Levine, Nadejda, Bracewell, Daniel G., Smales, Christopher Mark (2013) The dynamics of the CHO host cell protein profile during clarification and protein A capture in a platform antibody purification process. Biotechnology and Bioengineering, 110 (1). pp. 240-251. ISSN 0006-3592. (doi:10.1002/bit.24607) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:32470)

Hayes, Nandini V. L., Jossé, Lyne, Smales, Christopher Mark, Carden, Martin J. (2011) Modulation of Phosducin-Like Protein 3 (PhLP3) Levels Promotes Cytoskeletal Remodelling in a MAPK and RhoA-Dependent Manner. PLoS ONE, 6 (12). e28271. ISSN 1932-6203. (doi:10.1371/journal.pone.0028271) (KAR id:29212)

Hayes, Nandini V. L., Smales, Christopher Mark, Klappa, Peter (2009) Protein disulfide isomerase does not control recombinant IgG4 productivity in mammalian cell lines. Biotechnology and Bioengineering, 105 (4). pp. 770-779. ISSN 0006-3592. (doi:10.1002/bit.22587) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:29226)

Howard, Mark J., Smales, Christopher Mark (2005) NMR analysis of synthetic human serum albumin alpha-helix 28 identifies structural distortion upon amadori modification. Journal of Biological Chemistry, 280 (24). pp. 22582-22589. ISSN 0021-9258. (doi:10.1074/jbc.M501480200) (KAR id:5351)

J

Jossé, Lyne, Zhang, Lin, Smales, Christopher Mark (2018) Application of microRNA Targeted 3'UTRs to Repress DHFR Selection Marker Expression for Development of Recombinant Antibody Expressing CHO Cell Pools. Biotechnology Journal, 13 (10). Article Number 1800129. ISSN 1860-6768. (doi:10.1002/biot.201800129) (KAR id:68777)

Lonza Ltd (2017) Inhibition of protein degradation for improved production. WO2017118726A1. (doi:WO2017118726A1) (KAR id:85780)

Jossé, Lyne, Xie, J., Proud, C. G., Smales, Christopher Mark (2016) mTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GS-CHOK1 cells. Biochemical Journal, 473 (24). pp. 4651-4664. ISSN 0264-6021. (doi:10.1042/BCJ20160845) (KAR id:59811)

Jossé, Lyne and Smales, Christopher Mark and Tuite, Mick F. (2012) Engineering the Chaperone Network of CHO Cells for Optimal Recombinant Protein Production and Authenticity. In: Recombinant Gene Expression. Methods in Molecular Biology, 824 . Springer New York, pp. 595-608. ISBN 978-1-61779-433-9. (doi:10.1007/978-1-61779-433-9_32) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:33890)

Jossé, Lyne, Smales, Christopher Mark, Tuite, Mick F. (2010) Transient expression of human TorsinA enhances secretion of two functionally distinct proteins in cultured Chinese hamster ovary (CHO) cells. Biotechnology and Bioengineering, 105 (3). pp. 556-566. ISSN 0006-3592. (doi:10.1002/bit.22572) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:29222)

K

Knight, John R.P., Proud, Christopher G., Mallucci, Giovanna, von der Haar, Tobias, Smales, C. Mark, Willis, Anne E., Sansom, Owen J. (2022) Eukaryotic elongation factor 2 kinase activity is required for the phenotypes of the Rpl24 Bst mouse. Journal of Investigative Dermatology, 142 (12). 3346-3348.e1. ISSN 0022-202X. E-ISSN 1523-1747. (doi:10.1016/j.jid.2022.06.019) (KAR id:98186)

Knight, Tanya J., Povey, Jane F., Vito, Davide, Mohindra, Atul, Jaques, Colin M., Smales, C. Mark (2022) Manipulation of mRNA translation elongation influences the fragmentation of a biotherapeutic Fc‐fusion protein produced in CHO cells. Biotechnology and Bioengineering, 119 (12). pp. 3408-3420. ISSN 0006-3592. E-ISSN 1097-0290. (doi:10.1002/bit.28230) (KAR id:98242)

Knight, Tanya J, Turner, Sarah, Jaques, Colin M, Smales, Christopher Mark (2021) Cell Pool Selection of CHO Host and Recombinant Cell Pools by Inhibition of the Proteasome Results in Enhanced Product Yields and Cell Specific Productivity. Journal of Biotechnology, 337 . pp. 35-45. ISSN 0168-1656. (doi:10.1016/j.jbiotec.2021.06.019) (KAR id:89634)

Knight, John R.P., Garland, Gavin, Pöyry, Tuija, Mead, Emma, Vlahov, Nikola, Sfakianos, Aristeidis, Grosso, Stefano, De-Lima-Hedayioglu, Fabio, Mallucci, Giovanna R., von der Haar, Tobias, and others. (2020) Control of translation elongation in health and disease. Disease Models & Mechanisms, 13 (3). ISSN 1754-8403. E-ISSN 1754-8411. (doi:10.1242/dmm.043208) (KAR id:80923)

Knight, John R.P., Bastide, Amandine, Peretti, Diego, Roobol, Anne, Roobol, Joanne, Mallucci, Giovanna R., Smales, Christopher Mark, Willis, Anne E. (2016) Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis. RNA, 22 (4). pp. 623-635. ISSN 1355-8382. E-ISSN 1469-9001. (doi:10.1261/rna.054411.115) (KAR id:54861)

Knight, John, Bastide, Amandine, Roobol, Anne, Roobol, Joanne, Jackson, Thomas, Utami, Wahyu, Barrett, David, Smales, Christopher Mark, Willis, A. (2015) Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation. Biochemical Journal, 465 . pp. 227-238. ISSN 0264-6021. (doi:10.1042/BJ20141014) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:46572)

Kotov, Nikolay V., Bates, Declan G., Gizatullina, Antonina N., Gilaziev, Bulat, Khairullin, Rustem N, Chen, Michael ZQ, Drozdov, Ignat, Umezawa, Yoshinori, Hundhausen, Christian, Aleksandrov, Alexey, and others. (2011) Computational modelling elucidates the mechanism of ciliary regulation in health and disease. BMC Systems Biology, 5 . p. 143. ISSN 1752-0509. (doi:10.1186/1752-0509-5-143) (KAR id:36889)

L

Lintern, Katherine, Pathak, Mili, Smales, Christopher Mark, Howland, Kevin, Rathore, Anurag, Bracewell, Daniel G. (2016) Residual on column host cell protein analysis during lifetime studies of protein A chromatography. Journal of Chromatography A, 1461 . pp. 70-77. ISSN 0021-9673. (doi:10.1016/j.chroma.2016.07.055) (KAR id:56828)

M

Mulroney, Thomas E., Pöyry, Tuija, Yam-Puc, Juan Carlos, Rust, Maria, Harvey, Robert F., Kalmar, Lajos, Horner, Emily, Booth, Lucy, Ferreira, Alexander P., Stoneley, Mark, and others. (2023) N1-methylpseudouridylation of mRNA causes+1 ribosomal frameshifting. Nature, 625 (7993). pp. 189-194. ISSN 1476-4687. (doi:10.1038/s41586-023-06800-3) (KAR id:104726)

Moreno Sanchez, Dana (2022) Development of a new CHO Transient Expression Platform for mAb Production, Evaluation of Novel Viral Episome Maintenance Proteins for Transient Gene Expression. Master of Science by Research (MScRes) thesis, University of Kent,. (doi:10.22024/UniKent/01.02.93293) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:93293)

Martin, Sarah (2021) Development and Characterisation of HEK293T Cell Expression Systems for Enhanced Production of Recombinant AAV Viral Vectors. Doctor of Philosophy (PhD) thesis, University of Kent,. (doi:10.22024/UniKent/01.02.92760) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:92760)

Murphy, Niamh, Rooney, Barrie, Bhattacharyya, Tapan, Triana-Chavez, Omar, Krueger, Anja, Haslam, Stuart M., O’Rourke, Victoria, Pańczuk, Magdalena, Tsang, Jemima, Bickford-Smith, Jack, and others. (2020) Glycosylation of Trypanosoma cruzi TcI antigen reveals recognition by chagasic sera. Scientific Reports, 10 (1). Article Number 16395. ISSN 2045-2322. (doi:10.1038/s41598-020-73390-9) (KAR id:83387)

Martin, Andrew (2019) Development of a Rapid Point of Care Diagnostic Immunoassay for the Detection of P. aeruginosa Infections in Cystic Fibrosis Patients. Doctor of Philosophy (PhD) thesis, University of Kent. (KAR id:79904)

Mozzanino, Théo (2018) Engineering of the Secretory Pathway of CHO Cells for Recombinant Protein Production: Manipulation of SNARE Proteins. Doctor of Philosophy (PhD) thesis, University of Kent,. (KAR id:73387)

Migani, Damiano, Smales, Christopher Mark, Bracewell, Daniel G. (2017) Effects of lysosomal biotherapeutic recombinant protein expression on cell stress and protease and general host cell protein (HCP) release in Chinese hamster ovary cells. Biotechnology Progress, 33 (3). pp. 666-676. ISSN 8756-7938. E-ISSN 1520-6033. (doi:10.1002/btpr.2455) (KAR id:60754)

Mead, Emma J, Masterton, Rosalyn J., Feary, Marc, Obrezanova, Olga, Zhang, Lin, Young, Robert, Smales, Christopher Mark (2015) Biological Insights into the Expression of Translation Initiation Factors from Recombinant CHOK1SV Cell Lines and their Relationship to Enhanced Productivity. Biochemical Journal, 472 (3). pp. 261-273. ISSN 0264-6021. E-ISSN 1470-8728. (doi:10.1042/BJ20150928) (KAR id:52257)

Mead, Emma J., Masterton, Rosalyn J., von der Haar, Tobias, Tuite, Mick F., Smales, C. Mark (2014) Control and regulation of mRNA translation. Biochemical Society transactions, 42 (1). pp. 151-154. ISSN 0300-5127. E-ISSN 1470-8752. (doi:10.1042/BST20130259) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:68104)

Masterton, Rosalyn J., Smales, Christopher Mark (2014) The impact of process temperature on mammalian cell lines and the implications for the production of recombinant proteins in CHO cells. Pharmaceutical Bioprocessing, 2 (1). pp. 49-61. ISSN 2048-9145. (doi:10.4155/pbp.14.3) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:52456)

Mead, Emma J, Chiverton, Lesley M., Spurgeon, Sarah K., Martin, Elaine B., Montague, Gary A., Smales, Christopher Mark, von der Haar, Tobias (2012) Experimental and In Silico Modelling Analyses of the Gene Expression Pathway for Recombinant Antibody and By-Product Production in NS0 Cell Lines. PLoS ONE, 7 (10). e47422. ISSN 1932-6203. (doi:10.1371/journal.pone.0047422) (KAR id:34165)

Mead, Emma J and Smales, Christopher Mark (2011) mRNA Translation and Recombinant Gene Expression from Mammalian Cell Expression Systems. In: Comprehensive Biotechnology. Elsevier, pp. 403-409. ISBN 978-0-08-088504-9. (doi:10.1016/B978-0-08-088504-9.00043-X) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:34351)

Masterton, Rosalyn J., Roobol, Anne, Al-Fageeh, Mohamed B., Carden, Martin J., Smales, Christopher Mark (2010) Post-translational events of a model reporter protein proceed with higher fidelity and accuracy upon mild hypothermic culturing of Chinese hamster ovary cells. Biotechnology and Bioengineering, 105 (1). pp. 215-220. ISSN 0006-3592. (doi:10.1002/bit.22533) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:22908)

Mead, Emma J, Chiverton, Lesley M., Smales, Christopher Mark, von der Haar, Tobias (2009) Identification of the limitations on recombinant gene expression in CHO cell lines with varying luciferase production rates. Biotechnology and Bioengineering, 102 (6). pp. 1593-1602. ISSN 0006-3592. (doi:10.1002/bit.22201) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:22646)

Marchant, Rosalyn J., Al-Fageeh, Mohamed B., Underhill, Michele F., Racher, Andrew J., Smales, Christopher Mark (2008) Metabolic rates, growth phase, and mRNA levels influence cell-specific antibody production levels from in vitro-cultured mammalian cells at sub-physiological temperatures. Molecular Biotechnology, 39 (1). pp. 69-77. ISSN 1073-6085. (doi:10.1007/s12033-008-9032-0) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6234)

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Nagappa, Lakshmeesha N, Sato, Wakana, Alam, Farzana, Chengan, Kameshwari, Smales, Christopher Mark, von der Haar, Tobias, Polizzi, Karen M., Adamala, Katarzyna, Moore, Simon J. (2022) A ubiquitous amino acid source for prokaryotic and eukaryotic cell-free transcription-translation systems. Frontiers in Bioengineering and Biotechnology, 10 . Article Number 992708. ISSN 2296-4185. (doi:10.3389/fbioe.2022.992708) (KAR id:102961)

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Pekle, Eva (2020) Chinese Hamster Ovary Cell Line Development via Imaging Flow Cytometry and Directed Evolution. Doctor of Philosophy (PhD) thesis, University of Kent,. (doi:10.22024/UniKent/01.02.80690) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:80690)

Povey, Jane F., Saintas, Emily, Aderemi, Adewale V., Rothweiler, Florian, Zehner, Richard, Dirks, Wilhelm G., Cinatl, Jindrich, Racher, Andrew J., Wass, Mark N., Smales, C. Mark, and others. (2019) Intact-Cell MALDI-ToF Mass Spectrometry for the Authentication of Drug-Adapted Cancer Cell Lines. Cells, 8 (10). Article Number 1194. ISSN 2073-4409. (doi:10.3390/cells8101194) (KAR id:77013)

Pekle, Eva, Smith, Andrew, Rosignoli, Guglielmo, Sellick, Christopher, Smales, Christopher Mark, Pearce, Claire (2019) Application of Imaging Flow Cytometry for the Characterization of Intracellular Attributes in Chinese Hamster Ovary Cell Lines at the Single Cell Level. Biotechnology Journal, . Article Number 1800675. ISSN 1860-6768. (doi:10.1002/biot.201800675) (KAR id:73370)

Patel, Tulshi (2017) Manipulation and Exploitation of MicroRNAs for Enhanced Recombinant Protein Production in Chinese Hamster Ovary Cells. Doctor of Philosophy (PhD) thesis, University of Kent,. (doi:10.22024/UniKent/01.02.66224) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:66224)

Povey, Jane F., O’Malley, Christopher J., Root, Tracy, Martin, Elaine B., Montague, Gary A., Feary, Marc, Trim, Carol M., Lang, Dietmar A., Alldread, Richard, Racher, Andrew J., and others. (2014) Rapid high-throughput characterisation, classification and selection of recombinant mammalian cell line phenotypes using intact cell MALDI-ToF mass spectrometry fingerprinting and PLS-DA modelling. Journal of Biotechnology, 184 . pp. 84-93. ISSN 0168-1656. (doi:10.1016/j.jbiotec.2014.04.028) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:41424)

Peters, Shirley J., Smales, Christopher Mark, Henry, Alistair J., Stephens, Paul E., West, Shauna, Humphreys, David P. (2012) Engineering an Improved IgG4 Molecule with Reduced Disulfide Bond Heterogeneity and Increased Fab Domain Thermal Stability. Journal of Biological Chemistry, 287 (29). pp. 24525-24533. ISSN 0021-9258. (doi:10.1074/jbc.M112.369744) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:29892)

Povey, Jane F., Perez-Moral, Natalia, Noel, Timothy R., Parker, Roger, Howard, Mark J., Smales, Christopher Mark (2009) Investigating variables and mechanisms that influence protein integrity in low water content amorphous carbohydrate matrices. Biotechnology Progress, 25 (5). pp. 1217-27. ISSN 8756-7938. (doi:10.1002/btpr.207) (KAR id:28012)

Parsons, Joshua B., Dinesh, Sriramulu D., Deery, Evelyne, Leech, Helen K., Brindley, Amanda A., Heldt, Dana, Frank, Stefanie, Smales, Christopher Mark, Lunsdorf, Heinrich, Rambach, Alain, and others. (2008) Biochemical and Structural Insights into Bacterial Organelle Form and Biogenesis. Journal of Biological Chemistry, 283 (21). pp. 14366-14375. ISSN 0021-9258. (doi:10.1074/jbc.M709214200) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:35401)

Povey, Jane F., Howard, Mark J., Williamson, Richard A., Smales, Christopher Mark (2008) The effect of peptide glycation on protein secondary structure. Journal of Structural Biology, 161 (2). pp. 151-161. ISSN 1047-8477. (doi:10.1016/j.jsb.2007.10.004) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:22662)

Povey, Jane F., Smales, Christopher Mark, Hassard, S.J., Howard, Mark J. (2007) Comparison of the effects of 2,2,2-trifluoroethanol on peptide and protein structure and function. Journal of Structural Biology, 157 (2). pp. 329-338. ISSN 1047-8477. (doi:10.1016/j.jsb.2006.07.008) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:36)

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Roobol, Anne, Roobol, Joanne, Smith, Mark E., Carden, Martin J., Hershey, John W. B., Willis, Anne E., Smales, C. Mark (2020) Engineered transient and stable overexpression of translation factors eIF3i and eIF3c in CHOK1 and HEK293 cells gives enhanced cell growth associated with increased c-Myc expression and increased recombinant protein synthesis. Metabolic Engineering, 59 . pp. 98-105. ISSN 1096-7176. (doi:10.1016/j.ymben.2020.02.001) (KAR id:80226)

Rooney, Barrie C., Piening, Turid, Büscher, Philippe, Rogé, Stijn, Smales, Christopher Mark (2015) Expression of Trypanosoma brucei gambiense Antigens in Leishmania tarentolae. Potential for Use in Rapid Serodiagnostic Tests (RDTs). PLOS Neglected Tropical Diseases, 9 (12). Article Number 4271. ISSN 1935-2735. E-ISSN 1935-2735. (doi:10.1371/journal.pntd.0004271) (KAR id:54220)

Roobol, Anne, Roobol, Joanne, Bastide, Amandine, Knight, John, Willis, Anne, Smales, Christopher Mark (2015) p58(IPK) is an Inhibitor of the eIF2? Kinase GCN2 and its Localisation and Expression Underpin Protein Synthesis and ER Processing Capacity. Biochemical Journal, 465 . pp. 213-225. ISSN 0264-6021. (doi:10.1042/BJ20140852) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:46573)

Roobol, Anne, Roobol, Joanne, Carden, Martin J., Smith, Matthew E., Hershey, John W. B., Bastide, Amandine, Knight, John R. P., Willis, Anne E., Smales, Christopher Mark (2014) The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h. Biochemical Journal, 458 (2). pp. 213-224. ISSN 0264-6021. (doi:10.1042/BJ20130979) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:38990)

Roobol, Anne, Roobol, Joanne, Carden, Martin J., Bastide, Amandine, Willis, Anne E., Dunn, Warwick B., Goodacre, Royston, Smales, Christopher Mark (2011) ATR (ataxia telangiectasia mutated- and Rad3-related kinase) is activated by mild hypothermia in mammalian cells and subsequently activates p53. Biochemical Journal, 435 (2). pp. 499-508. ISSN 0264-6021. (doi:10.1042/BJ20101303) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:29211)

Reid, C.Q., Tait, Andrew S., Baldascini, H., Mohindra, A., Racher, Andrew J., Bilsborough, S., Smales, Christopher Mark, Hoare, Michael (2010) Rapid whole monoclonal antibody analysis by mass spectrometry: An Ultra scale-down study of the effect of harvesting by centrifugation on the post-translational modification profile. Biotechnology and Bioengineering, 107 (1). pp. 85-95. ISSN 0006-3592. (doi:10.1002/bit.22790) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:29225)

Roobol, Anne, Carden, Martin J., Newsam, Ray J., Smales, Christopher Mark (2009) Biochemical insights into the mechanisms central to the response of mammalian cells to cold stress and subsequent rewarming. FEBS Journal, 276 (1). pp. 286-302. ISSN 1742-464X. (doi:10.1111/j.1742-4658.2008.06781.x) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:22877)

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Sathiyavasan, Saranya (2023) The effect of L-arginine supplementation on model in vitro cultured cellular metabolism that underpins metabolic disorders. Doctor of Philosophy (PhD) thesis, University of Kent,. (doi:10.22024/UniKent/01.02.102212) (KAR id:102212)

Skrika-Alexopoulos, Eleftheria, Smales, Christopher Mark (2023) Isolation and characterisation of exosomes from Chinese hamster ovary (CHO) cells. Biotechnology Letters, 45 (4). pp. 425-437. ISSN 1573-6776. (doi:10.1007/s10529-023-03353-3) (KAR id:99983)

Seymour, Harry (2022) Towards Development of Novel Selection Systems that Utilise ER Signal Peptides for the Generation of Recombinant Protein Expressing Mammalian Cell Lines. Master of Research (MRes) thesis, University of Kent,. (doi:10.22024/UniKent/01.02.93442) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:93442)

Saintas, Emily, Abrahams, Liam, Ahmed, Gulshan T, Ajakaiye, Anu-Oluwa M, AlHumaidi, Abdulaziz S H A M, Ashmore-Harris, Candice, Clark, Iain, Dura, Usha K, Fixmer, Carine N, Ike-Morris, Chinedu, and others. (2017) Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS. PLoS ONE, 12 (2). Article Number 172140. ISSN 1932-6203. (doi:10.1371/journal.pone.0172140) (KAR id:60364)

Smales, Christopher Mark (2008) Proceedings from the 8th PEACe Conference on Protein Expression in Animal Cells, Angra Dos Reis, Brazil, September 16-20, 2007. Molecular Biotechnology, 39 (2). p. 87. ISSN 1073-6085. (doi:10.1007/s12033-008-9053-8) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:15202)

Scott, Sarah J. and Marchant, Rosalyn J. and Al-Fageeh, Mohamed B. and Underhill, Michele F. and Smales, Christopher Mark (2006) The molecular response(s) during cellular adaptation to, and recovery from, sub-physiological temperatures. In: Al-Rubeai, Mohamed and Fussenegger, Martin M., eds. Systems Biology. Cell Engineering (5). Springer, Netherlands, pp. 185-212. ISBN 978-1-4020-5251-4. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6255)

Smales, Christopher Mark and James, David C., eds. (2005) Characterization of therapeutic proteins by membrane and in-gel tryptic digestion. Methods in Molecular Biology, 308 . Humana Press, 482 pp. ISBN 978-1-58829-390-9. (doi:10.1385/1-59259-922-2:375) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6221)

Smales, Christopher Mark, Dinnis, Diane M., Stansfield, Scott H., Alete, Daniel E., Sage, E.A., Birch, John R., Racher, Andrew J., Marshall, Carol T., James, David C. (2004) Comparative proteomic analysis of GS-NSO murine myeloma cell lines with varying recombinant monoclonal antibody production rate. Biotechnology and Bioengineering, 88 (4). pp. 474-488. ISSN 0006-3592. (doi:10.1002/bit.20272) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:60)

Smales, Christopher Mark, Birch, John R., Racher, Andrew J., Marshall, Carol T., James, David C. (2003) Evaluation of individual protein errors in silver-stained two-dimensional gels. Biochemical and Biophysical Research Communications, 306 (4). pp. 1050-1055. ISSN 0006-291X. (doi:10.1016/S0006-291X(03)01115-X) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6213)

Smales, Christopher Mark, Blackwell, Leonard F. (2003) Lysozyme conjugate immune complex formation and the effects on substrate hydrolysis. Biochemical and Biophysical Research Communications, 304 (4). pp. 818-824. ISSN 0006-291X. (doi:10.1016/S0006-291X(03)00684-3) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6215)

Smales, Christopher Mark, Pepper, Duncan S., James, David C. (2002) Protein modification during anti-viral heat-treatment bioprocessing of factor VIII concentrates, factor IX concentrates, and model proteins in the presence of sucrose. Biotechnology and Bioengineering, 77 (1). pp. 37-48. ISSN 0006-3592. (doi:10.1002/bit.10161) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:62)

Smales, Christopher Mark, Blackwell, Leonard F. (2002) Purification and characterization of lysozyme-pregnanediol glucuronide conjugates: the effect of the hapten and coupling reagent on the substitution level, sites of acylation and the consequences for the development of future immunoassays. Biotechnology and Applied Biochemistry, 36 (2). pp. 101-110. ISSN 0885-4513. (doi:10.1042/ba20020038) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6211)

Smales, Christopher Mark, Pepper, Duncan S., James, David C. (2001) Protein Modifications during Antiviral Heat Bioprocessing and Subsequent Storage. Biotechnology Progress, 17 (5). pp. 974-978. ISSN 8756-7938. (doi:10.1021/bp010086f) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6208)

Smales, Christopher Mark, Pepper, Duncan S., James, David C. (2001) Evaluation of Protein Modification during Anti-Viral Heat Bioprocessing by Electrospray Ionization Mass Spectrometry. Rapid Communications in Mass Spectrometry, 15 (5). pp. 351-356. ISSN 0951-4198. (doi:10.1002/rcm.232) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6210)

Smales, Christopher Mark, Pepper, Duncan S., James, David C. (2000) Mechanisms of protein modification during model anti-viral heat-treatment bioprocessing of beta-lactoglobulin variant A in the presence of sucrose. Biotechnology and Applied Biochemistry, 32 (2). pp. 109-119. ISSN 0885-4513. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6206)

Smales, Christopher Mark, Pepper, Duncan S., James, David C. (2000) Protein modification during antiviral heat bioprocessing. Biotechnology and Bioengineering, 67 (2). pp. 177-188. ISSN 0006-3592. (doi:10.1002/(SICI)1097-0290(20000120)67:2<177::AID-BIT7>3.0.CO;2-3) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6207)

Smales, Christopher Mark, Moore, Christopher H., Blackwell, Leonard F. (1999) Characterization of lysozyme-estrone glucuronide conjugates. The effect of the coupling reagent on the substitution level and sites of acylation. Bioconjugate Chemistry, 10 (4). pp. 693-700. ISSN 1043-1802. (doi:10.1021/bc9900441) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6205)

Smales, C. Mark, Harding, David R.K. (1999) A novel target synthesis laboratory for students. Journal of Chemical Education, 76 (11). pp. 1558-1560. ISSN 0021-9584. (doi:10.1021/ed076p1558) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6204)

Smales, Christopher Mark, Elgar, David F., Moore, Christopher H., Blackwell, Leonard F. (1998) Acid-polyacrylamide gel electrophoresis of lysozyme-estrone glucuronide conjugates. Bioconjugate Chemistry, 9 (6). pp. 838-841. ISSN 1043-1802. (doi:10.1021/bc9701914) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6203)

Smales, Christopher Mark, Blackwell, Leonard F., Waters, J.M., Burrell, A.K. (1997) An estrone-glucuronide conjugate. Acta Crystallographica Section C-Crystal Structure Communications, 53 (part 8). pp. 1082-1084. ISSN 0108-2701. (doi:10.1107/s0108270197004629) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6202)

Smales, Christopher Mark, Cooke, D.G., Blackwell, Leonard F. (1994) Use of ion-exchange and hydrophobic-interaction chromatography for the rapid purification of lysozyme-estrone glucuronide conjugates. Journal of Chromatography B-Biomedical Applications, 662 (1). pp. 3-14. ISSN 0378-4347. (doi:10.1016/0378-4347(94)00381-5) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6201)

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Talbot, Natalie Elizabeth (2020) Investigating the Relationship between Chinese Hamster Ovary Cellular Stress Responses, Culture Harvest Day and Formulated mAb Stability. Doctor of Philosophy (PhD) thesis, University of Kent,. (doi:10.22024/UniKent/01.02.80777) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:80777)

Talbot, Natalie E., Mead, Emma J, Davies, Stephanie Ann, Uddin, Shahid, Smales, Christopher Mark (2019) Application of ER Stress Biomarkers to Predict Formulated Monoclonal Antibody Stability. Biotechnology Journal, 14 (10). Article Number 1900024. ISSN 1860-6768. (doi:10.1002/biot.201900024) (KAR id:74133)

Tamošaitis, Linas, Smales, Mark, C (2018) Meta-analysis of publicly available Chinese hamster ovary (CHO) cell transcriptomic datasets for identifying engineering targets to enhance recombinant protein yields. Biotechnology Journal, 13 (10). Article Number 1800066. ISSN 1860-6768. (doi:10.1002/biot.201800066) (KAR id:67426)

Tunjung, Woro Anindito Sri, Cinatl, Jindrich, Michaelis, Martin, Smales, Christopher Mark (2015) Anti-Cancer Effect of Kaffir Lime (Citrus Hystrix DC) Leaf Extract in Cervical Cancer and Neuroblastoma Cell Lines. Procedia Chemistry, 14 . pp. 465-468. ISSN 1876-6196. (doi:10.1016/j.proche.2015.03.062) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:52254)

Tait, Andrew S., Hogwood, Catherine E.M., Smales, Christopher Mark, Bracewell, Daniel G. (2011) Host cell protein dynamics in the supernatant of a mAb producing CHO cell line. Biotechnology and Bioengineering, 109 (4). pp. 971-982. ISSN 0006-3592. (doi:10.1002/bit.24383) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:29205)

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Uddin, Shahid (2019) Application of Instrumental Analysis Methods to Characterisation of Monoclonal Antibody-Based Formulations. Doctor of Philosophy (PhD) thesis, University of Kent,. (KAR id:79154)

Underhill, Michele F., Smales, Christopher Mark (2007) The cold-shock response in mammalian cells: investigating the HeLa cell cold-shock proteome. Cytotechnology, 53 (1-3). pp. 47-53. ISSN 0920-9069. (doi:10.1007/s10616-007-9048-5) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:2934)

Underhill, Michele F., Smales, Christopher Mark, Naylor, Louise H., Birch, John R., James, David C. (2007) Transient Gene Expression Levels from Multigene Expression Vectors. Biotechnology Progress, 23 (2). pp. 435-443. ISSN 8756-7938. (doi:10.1021/bp060225z) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:2935)

Underhill, Michele F., Marchant, Rosalyn J., Carden, Martin J., James, David C., Smales, Christopher Mark (2006) On the effect of transient expression of mutated eIF2 alpha and eIF4E eukaryotic translation initiation factors on reporter gene expression in mammalian cells upon cold-shock. Molecular Biotechnology, 34 (2). pp. 141-149. ISSN 1073-6085. (doi:10.1385/MB:34:2:141) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6223)

Underhill, Michele F., Birch, John R., Smales, Christopher Mark, Naylor, Louise H. (2005) eIF2 alpha phosphorylation, stress perception, and the shutdown of global protein synthesis in cultured CHO cells. Biotechnology and Bioengineering, 89 (7). pp. 805-814. ISSN 0006-3592. (doi:10.1002/bit.20403) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6220)

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von der Haar, Tobias, Mulroney, Thomas E., Hedayioglu, Fabio, Kurusamy, Sathishkuma, Rust, Maria, Lilley, Kathryn S., Thaventhiran, James E., Willis, Anne E., Smales, C. Mark (2023) Translation of in vitro -transcribed RNA therapeutics. Frontiers in Molecular Biosciences, 10 . Article Number 1128067. ISSN 2296-889X. (doi:10.3389/fmolb.2023.1128067) (KAR id:100172)

Vito, Davide, Eriksen, Jens Christian, Skjødt, Christian, Weilguny, Dietmar, Rasmussen, Søren K., Smales, C. Mark (2020) Defining lncRNAs Correlated with CHO Cell Growth and IgG Productivity by RNA-Seq. iScience, 23 (1). Article Number 100785. ISSN 2589-0042. (doi:10.1016/j.isci.2019.100785) (KAR id:79922)

Vito, Davide (2019) A Journey Through the Dark: Exploration of Long Non-Coding RNAs and tRNAs in Chinese Hamster Ovary Cells for Recombinant Protein Production. Doctor of Philosophy (PhD) thesis, University of Kent,. (KAR id:80492)

Vito, Davide, Smales, Christopher Mark (2018) Engineering of the Cellular Translational Machinery and Non-Coding RNAs to Enhance CHO Cell Growth, Recombinant Product Yields and Quality. Current Opinion in Chemical Engineering, 22 . pp. 199-208. ISSN 2211-3398. (doi:10.1016/j.coche.2018.11.002) (KAR id:89627)

Vito, Davide, Smales, Christopher Mark (2018) The Long Non-Coding RNA Transcriptome Landscape in CHO Cells Under Batch and Fed-Batch Conditions. Biotechnology Journal, 13 (10). Article Number 1800122. ISSN 1860-6768. (doi:10.1002/biot.201800122) (KAR id:67183)

Vasilev, Nikolay, Smales, Christopher Mark, Schillberg, Stefan, Fischer, Rainer, Schiermeyer, Andreas (2016) Developments in the production of mucosal antibodies in plants. Biotechnology Advances, 34 (2). pp. 77-87. ISSN 0734-9750. (doi:10.1016/j.biotechadv.2015.11.002) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:54273)

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Williams, Marc J., Sánchez, Enrique, Aluri, Esther Rani, Douglas, Fraser J., MacLaren, Donald A., Collins, Oonagh M., Cussen, Edmund J., Budge, James D., Sanders, Lara C., Michaelis, Martin, and others. (2016) Microwave-assisted synthesis of highly crystalline, multifunctional iron oxide nanocomposites for imaging applications. RSC Advances, 6 (87). pp. 83520-83528. ISSN 2046-2069. (doi:10.1039/c6ra11819d) (KAR id:57882)

Wagstaff, Jane L., Masterton, Rosalyn J., Povey, Jane F., Smales, Christopher Mark, Howard, Mark J. (2013) 1H NMR Spectroscopy Profiling of Metabolic Reprogramming of Chinese Hamster Ovary Cells upon a Temperature Shift during Culture. PLoS ONE, 8 (N/A). e77195-e77195. ISSN 1932-6203. (doi:10.1371/journal.pone.0077195) (KAR id:35491)

Weeks, Mark E., von Caron, G.N., James, David C., Smales, Christopher Mark, Robinson, Gary K. (2006) Monitoring changes in nisin susceptibility of Listeria monocytogenes Scott A as an indicator of growth phase using FACS. Journal of Microbiological Methods, 66 (1). pp. 43-55. ISSN 0167-7012. (doi:10.1016/j.mimet.2005.10.008) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6227)

Weeks, Mark E., James, David C., Robinson, Gary K., Smales, Christopher Mark (2004) Global changes in gene expression observed at the transition from growth to stationary phase in Listeria monocytogenes ScottA batch culture. Proteomics, 4 (1). pp. 123-135. ISSN 1615-9853. (doi:10.1002/pmic.200300527) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:61)

Y

Lonza Inc (2019) Methods of cell selection and modifying cell metabolism. WO2019152876A2. (doi:WO2019152876A2) (KAR id:85782)

This list was generated on Mon Apr 22 19:33:59 2024 BST.