Microwave-assisted synthesis of highly crystalline, multifunctional iron oxide nanocomposites for imaging applications

Williams, Marc J., Sánchez, Enrique, Aluri, Esther Rani, Douglas, Fraser J., MacLaren, Donald A., Collins, Oonagh M., Cussen, Edmund J., Budge, James D., Sanders, Lara C., Michaelis, Martin, and others. (2016) Microwave-assisted synthesis of highly crystalline, multifunctional iron oxide nanocomposites for imaging applications. RSC Advances, 6 (87). pp. 83520-83528. ISSN 2046-2069. (doi:10.1039/c6ra11819d) (KAR id:57882)

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Official URL: http://doi.org/10.1039/c6ra11819d

Abstract

We report a reproducible single-step, microwave-assisted approach for the preparation of multifunctional magnetic nanocomposites comprising superparamagnetic iron oxide (Fe3O4) cores, a polyelectrolyte stabilizer and an organic dye with no requirement for post-processing. The stabilisers poly(sodium 4-styrenesulfonate) (PSSS) and sodium polyphosphate (SPP) have been thoroughly investigated and from analysis using electron microscopy, dynamic light scattering measurements, magnetic hysteresis and magnetic resonance (MR) imaging, we show that the higher degree of Fe3O4 nanoparticle crystallinity achieved with the PSSS stabiliser leads to enhanced magnetic behaviour and thus better contrast agent relaxivity compared to the less crystalline, poorly defined particles obtained when SPP is employed as a stabiliser. We also demonstrate the potential for obtaining a multifunctional magnetic-fluorescent nanocomposite using our microwave-assisted synthesis. In this manner, we demonstrate the intimate link between synthetic methodology (microwave heating with a polyelectrolyte stabilizer) and the resulting properties (particle size, shape, and magnetism) and how this underpins the functionality of the resulting nanocomposites as agents for biomedical imaging.

Item Type:	Article
DOI/Identification number:	10.1039/c6ra11819d
Subjects:	Q Science
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	Mark Smales
Date Deposited:	14 Oct 2016 11:01 UTC
Last Modified:	05 Nov 2024 10:48 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/57882 (The current URI for this page, for reference purposes)

University of Kent Author Information

Michaelis, Martin.

Creator's ORCID:	https://orcid.org/0000-0002-5710-5888
CReDIT Contributor Roles:

Smales, Christopher Mark.

Creator's ORCID:	https://orcid.org/0000-0002-2762-4724
CReDIT Contributor Roles:

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