Control and regulation of the cellular responses to cold shock: the responses in yeast and mammalian systems

Al-Fageeh, Mohamed B. and Smales, C. Mark (2006) Control and regulation of the cellular responses to cold shock: the responses in yeast and mammalian systems. Biochemical Journal, 397 . pp. 247-259. ISSN 0264-6021. (doi:https://doi.org/10.1042/BJ20060166) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1042/BJ20060166

Abstract

Although the cold-shock response has now been studied in a number of different organisms for several decades, it is only in the last few years that we have begun to understand the molecular mechanisms that govern adaptation to cold stress. Notably, all organisms from prokaryotes to plants and higher eukaryotes respond to cold shock in a comparatively similar manner. The general response of cells to cold stress is the elite and rapid overexpression of a small group of proteins, the so-called CSPs (cold-shock proteins). The most well characterized CSP is CspA, the major CSP expressed in Escherichia coli upon temperature downshift. More recently, a number of reports have shown that exposing yeast or mammalian cells to sub-physiological temperatures (< 30 or < 37 degrees C respectively) invokes a co-ordinated cellular response involving modulation of transcription, translation, metabolism, the cell cycle and the cell cytoskeleton. In the present review, we summarize the regulation and role of coldshock genes and proteins in the adaptive response upon decreased temperature with particular reference to yeast and in vitro cultured mammalian cells. Finally, we present an integrated model for the co-ordinated responses required to maintain the viability and integrity of mammalian cells upon mild hypothermic cold shock.

Item Type: Article
Additional information: Part 2
Uncontrolled keywords: cellular response; cold-shock protein; cold-shock response; control of gene expression; sub-physiological temperature; yeast
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Mark Smales
Date Deposited: 03 Sep 2008 07:15 UTC
Last Modified: 09 Apr 2014 09:01 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/6225 (The current URI for this page, for reference purposes)
  • Depositors only (login required):