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Biotherapeutic protein formulation variables influence protein integrity and can promote post-translational modifications as shown using chicken egg white lysozyme as a model system.

Gourbatsi, Evdoxia, Povey, Jane F., Uddin, Shahid, Smales, Christopher Mark (2016) Biotherapeutic protein formulation variables influence protein integrity and can promote post-translational modifications as shown using chicken egg white lysozyme as a model system. Biotechnology Letters, 38 (4). pp. 589-596. ISSN 0141-5492. E-ISSN 1573-6776. (doi:10.1007/s10529-015-2014-y) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:54863)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://doi.org/10.1007/s10529-015-2014-y

Abstract

Objectives

Results

Conclusions

Peptide models may mirror the stability of proteins, or regions of proteins, in the same formulations and be used to help develop a rapid screen of formulations for stabilisation of biotherapeutic proteins.

Item Type: Article
DOI/Identification number: 10.1007/s10529-015-2014-y
Uncontrolled keywords: Protein formulation; Mass spectrometry; Post-translational modification; Aggregation; Peptide model;
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Mark Smales
Date Deposited: 11 Apr 2016 09:07 UTC
Last Modified: 29 May 2019 17:11 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/54863 (The current URI for this page, for reference purposes)
Smales, Christopher Mark: https://orcid.org/0000-0002-2762-4724
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