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Anti-Cancer Effect of Kaffir Lime (Citrus Hystrix DC) Leaf Extract in Cervical Cancer and Neuroblastoma Cell Lines

Tunjung, Woro Anindito Sri, Cinatl, Jindrich, Michaelis, Martin, Smales, Christopher Mark (2015) Anti-Cancer Effect of Kaffir Lime (Citrus Hystrix DC) Leaf Extract in Cervical Cancer and Neuroblastoma Cell Lines. Procedia Chemistry, 14 . pp. 465-468. ISSN 1876-6196. (doi:10.1016/j.proche.2015.03.062) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
http://doi.org/10.1016/j.proche.2015.03.062

Abstract

Previous study showed that kaffir lime leaf contains alkaloid, flavonoid, terpenoid, tannin and saponin. The objective of this study was to examine the cytotoxic effect of kaffir lime leaf extract on cervical cancer and neuroblastoma cell lines. The method used for this research to determine cell viability was an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results showed that an ethyl acetate extract had an IC50 for HeLa cells, UKF-NB3, IMR-5 and SK-N-AS parental cells of 40.7 ?g · mL–1, 28.4 ?g · mL–1, 14.1 ?g · mL–1, and 25.2 ?g · mL–1 respectively. Furthermore, the IC50 of chloroform extracts for HeLa cells, UKF-NB3, IMR-5 and SK-N-AS parental were 17.6 ?g · mL–1, 18.9 ?g · mL–1, 6.4 ?g · mL–1, and 9.4 ?g · mL–1 respectively. These data showed that kaffir lime extract reduces the viability of cervical and neuroblastoma cell lines and may have potential as anti-cancer compounds.

Item Type: Article
DOI/Identification number: 10.1016/j.proche.2015.03.062
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Mark Smales
Date Deposited: 23 Nov 2015 12:10 UTC
Last Modified: 29 May 2019 16:29 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/52254 (The current URI for this page, for reference purposes)
Smales, Christopher Mark: https://orcid.org/0000-0002-2762-4724
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