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Number of items: 40.

A

Al-Fageeh, Mohamed B., Marchant, Rosalyn J., Carden, Martin J., Smales, Christopher Mark (2006) The cold-shock response in cultured mammalian cells: Harnessing the response for the improvement of recombinant protein production. Biotechnology and Bioengineering, 93 (5). pp. 829-835. ISSN 0006-3592. (doi:10.1002/bit.20789) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6229)

Alston, Mark J., Freedman, Robert B. (2002) A comparison of lipase-catalysed ester and lactone synthesis in low-water systems: analysis of optimum water activity. Biotechnology and Bioengineering, 77 (6). pp. 641-650. ISSN 0006-3592. (doi:10.1002/bit.10102) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6727)

Alston, Mark J., Freedman, Robert B. (2002) The water-dependence of the catalytic activity of bilirubin oxidase suspensions in low-water systems. Biotechnology and Bioengineering, 77 (6). pp. 651-657. ISSN 0006-3592. (doi:10.1002/bit.10103) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6726)

B

Browning, Douglas F., Richards, Kirsty L., Peswani, Amber R., Roobol, Jo, Busby, Stephen J. W., Robinson, Colin (2017) Escherichia coli ‘TatExpress’ strains super-secrete human growth hormone into the bacterial periplasm by the Tat pathway. Biotechnology and Bioengineering, 114 (12). pp. 2828-2836. ISSN 0006-3592. E-ISSN 1097-0290. (doi:10.1002/bit.26434) (KAR id:63243)

Branston, Steven D., Matos, Cristina F.R.O., Freedman, Robert B., Robinson, Colin, Keshavarz-Moore, Eli (2011) Investigation of the impact of Tat export pathway enhancement on E. coli culture, protein production and early stage recovery. Biotechnology and Bioengineering, 109 (4). pp. 983-991. ISSN 0006-3592. (doi:10.1002/bit.24384) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:37729)

Baker, Kym N., Rendall, Mark H., Hills, Anna E., Hoare, Michael, Freedman, Robert B., James, David C. (2001) Metabolic Control of Recombinant Protein N-glycan Processing in NS0 and CHO Cells. Biotechnology and Bioengineering, 73 (3). pp. 188-202. ISSN 0006-3592. (doi:10.1002/bit.1051) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6498)

Bracewell, Daniel G., Francis, Richard, Smales, Christopher Mark (2015) The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control. Biotechnology and Bioengineering, 112 (9). pp. 1727-1737. ISSN 0006-3592. (doi:10.1002/bit.25628) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:50203)

C

Coppen, S.R, Newsam, Ray J., Bull, Alan T., Baines, Anthony J. (1995) Heterogeneity within Populations of Recombination Chinese-Haster Ovary Cells Epressing Human Interferon Gamma. Biotechnology and Bioengineering, 46 (2). pp. 147-158. ISSN 0006-3592. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:19772)

D

De Poi, Stuart P, Xie, Jianling, Smales, Christopher Mark, Proud, Christopher G (2021) Constitutively-active Rheb mutants [T23M] and [E40K] drive increased production and secretion of recombinant protein in Chinese hamster ovary cells. Biotechnology and Bioengineering, 118 (7). pp. 2422-2434. ISSN 0006-3592. (doi:10.1002/bit.27748) (KAR id:89632)

Dinnis, Diane M., Stansfield, Scott H., Schlatter, Stefan, Smales, Christopher Mark, Alete, Daniel E., Birch, John R., Racher, Andrew J., Marshal, Carol T., Nielsen, Lars K., James, David C. and others. (2006) Functional proteomic analysis of GS-NS0 murine myeloma cell lines with varying recombinant monoclonal antibody production rate. Biotechnology and Bioengineering, 94 (5). pp. 830-841. ISSN 0006-3592. (doi:10.1002/bit.20899) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6226)

G

Guerrero‐Montero, Isabel, Richards, Kirsty L., Jawara, Chillel, Browning, Douglas F., Peswani, Amber R., Labrit, Mickael, Allen, Matthew, Aubry, Cedric, Davé, Emma, Humphreys, David P., and others. (2019) Escherichia coli ‘TatExpress’ strains export several g/L human growth hormone to the periplasm by the Tat pathway. Biotechnology and Bioengineering, 116 (12). pp. 3282-3291. ISSN 0006-3592. (doi:10.1002/bit.27147) (KAR id:76018)

Goldman, Merlin H., James, David C., Rendall, Mark H., Ison, Andrew P., Hoare, Michael, Bull, Alan T. (1998) Monitoring recombinant human interferon-gamma n-glycosylation during perfused fluidized-bed and stirred-tank batch culture of CHO cells. Biotechnology and Bioengineering, 60 (5). pp. 596-607. ISSN 0006-3592. (doi:10.1002/(SICI)1097-0290(19981205)60:5<596::AID-BIT10>3.0.CO;2-5) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:17773)

H

Hooker, Andrew D., Green, Nicola H., Baines, Anthony J., Bull, Alan T., Jenkins, Nigel, Strange, Philip G., James, David C. (1999) Constraints on the transport and glycosylation of recombinant IFN-gamma in Chinese hamster ovary and insect cells. Biotechnology and Bioengineering, 63 (5). pp. 559-572. ISSN 0006-3592. (doi:10.1002/(SICI)1097-0290(19990605)63:5<559::AID-BIT6>3.0.CO;2-L) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:16851)

Hayter, Paul M., Curling, Elizabeth M., Baines, Anthony J., Jenkins, Nigel, Salmon, Ian, Strange, Philip G., Tong, Jeremy M., Bull, Alan T. (1992) Glucose-Limited Chemostat Culture of Chinese-Hamster Ovary Cells Producing Recombinant Human Interferon-Gamma. Biotechnology and Bioengineering, 39 (3). pp. 327-335. ISSN 0006-3592. (doi:10.1002/bit.260390311) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:22611)

Hothersall, Joanne, Lai, Sandie, Zhang, Nan, Godfrey, Rita E., Ruanto, Patcharawarin, Bischoff, Sarah, Robinson, Colin, Overton, Tim W., Busby, Stephen J. W., Browning, Douglas F. and others. (2022) Inexpensive protein overexpression driven by the NarL transcription activator protein. Biotechnology and Bioengineering, 119 (6). pp. 1614-1623. ISSN 0006-3592. (doi:10.1002/bit.28071) (KAR id:96806)

Hills, Anna E., Patel, Ashvin, Boyd, Paul, James, David C. (2001) Metabolic control of recombinant monoclonal antibody N-glycosylation in GS-NS0 cells. Biotechnology and Bioengineering, 75 (2). pp. 239-251. ISSN 0006-3592. (doi:10.1002/bit.10022) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6497)

Hooker, Andrew D., Goldman, Merlin H., Markham, Nicola H., James, David C., Ison, Andrew P., Bull, Alan T., Strange, Philip G., Salmon, Ian, Baines, Anthony J., Jenkins, Nigel and others. (2007) N-Glycans of Recombinant Human Interferon-Gamma Change During Batch Culture of Chinese - Hamster Ovary Cells. Biotechnology and Bioengineering, 97 (2). pp. 410-424. ISSN 0006-3592. (doi:10.1002/bit.260480612) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:19603)

Hayes, Nandini V. L., Smales, Christopher Mark, Klappa, Peter (2009) Protein disulfide isomerase does not control recombinant IgG4 productivity in mammalian cell lines. Biotechnology and Bioengineering, 105 (4). pp. 770-779. ISSN 0006-3592. (doi:10.1002/bit.22587) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:29226)

Hussain, Hirra, Patel, Tulshi, Ozanne, Angelica M.S., Vito, Davide, Ellis, Mark, Hinchliffe, Matthew, Humphreys, David P., Stephens, Paul E., Sweeney, Bernie, White, James, and others. (2021) A comparative analysis of recombinant Fab and full‐length antibody production in Chinese hamster ovary cells. Biotechnology and Bioengineering, 118 (12). pp. 4815-4828. ISSN 1097-0290. (doi:10.1002/bit.27944) (KAR id:102666)

Hogwood, Catherine E.M., Tait, Andrew S., Koloteva-Levine, Nadejda, Bracewell, Daniel G., Smales, Christopher Mark (2013) The dynamics of the CHO host cell protein profile during clarification and protein A capture in a platform antibody purification process. Biotechnology and Bioengineering, 110 (1). pp. 240-251. ISSN 0006-3592. (doi:10.1002/bit.24607) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:32470)

Hayter, Peter M., Curling, Elizabeth M., Gould, Malcolm L., Baines, Anthony J., Jenkins, Nigel, Salmon, Ian, Strange, Philip G., Bull, Alan T. (1993) The effect of the dilution rate on CHO cell physiology and recombinant interferon-gamma production in glucose-limited chemostat culture. Biotechnology and Bioengineering, 42 (9). pp. 1077-1085. ISSN 0006-3592. (doi:10.1002/bit.260420909) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:22134)

J

James, David C., Freedman, Robert B., Hoare, Michael, Ogonah, Olotu W., Rooney, Barrie C., Larionov, Oleg A., Dobrovolsky, Vasily N., Lagutin, Oleg V., Jenkins, Nigel (1998) N-Glycosylation of Recominant Human Interferon-Gamma Produced in Deferent Animal Expression System. Biotechnology and Bioengineering, 60 (5). pp. 59-607. ISSN 0006-3592. (doi:10.1002/(SICI)1097-0290(19981205)60:5<596::AID-BIT10>3.0.CO;2-) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:19617)

Jenkins, Nigel, Hovey, Alison (1993) Temperature control of growth and productivity in mutant Chinese-hamster ovary cells synthesizing a recombinant protein. Biotechnology and Bioengineering, 42 (9). pp. 1029-1036. ISSN 0006-3592. (doi:10.1002/bit.260420903) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:22154)

Jossé, Lyne, Smales, Christopher Mark, Tuite, Mick F. (2010) Transient expression of human TorsinA enhances secretion of two functionally distinct proteins in cultured Chinese hamster ovary (CHO) cells. Biotechnology and Bioengineering, 105 (3). pp. 556-566. ISSN 0006-3592. (doi:10.1002/bit.22572) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:29222)

K

Knight, Tanya J., Povey, Jane F., Vito, Davide, Mohindra, Atul, Jaques, Colin M., Smales, C. Mark (2022) Manipulation of mRNA translation elongation influences the fragmentation of a biotherapeutic Fc‐fusion protein produced in CHO cells. Biotechnology and Bioengineering, 119 (12). pp. 3408-3420. ISSN 0006-3592. E-ISSN 1097-0290. (doi:10.1002/bit.28230) (KAR id:98242)

M

Matos, Cristina F.R.O., Branston, Steven D., Albiniak, Anna M., Dhanoya, Arjun, Freedman, Robert B., Keshavarz-Moore, Eli, Robinson, Colin (2012) High-yield export of a native heterologous protein to the periplasm by the tat translocation pathway in Escherichia coli. Biotechnology and Bioengineering, 109 (10). pp. 2533-2542. ISSN 0006-3592. (doi:10.1002/bit.24535) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:34575)

Mead, Emma J, Chiverton, Lesley M., Smales, Christopher Mark, von der Haar, Tobias (2009) Identification of the limitations on recombinant gene expression in CHO cell lines with varying luciferase production rates. Biotechnology and Bioengineering, 102 (6). pp. 1593-1602. ISSN 0006-3592. (doi:10.1002/bit.22201) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:22646)

Millward, H.R., Bellhouse, B.J., Nicholson, Andrea M., Beeton, S., Jenkins, Nigel, Knowles, Christopher J. (1994) Mammalian-cell damage in a novel membrane bioreactor. Biotechnology and Bioengineering, 43 (9). pp. 899-906. ISSN 0006-3592. (doi:10.1002/bit.260430909) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:19911)

Masterton, Rosalyn J., Roobol, Anne, Al-Fageeh, Mohamed B., Carden, Martin J., Smales, Christopher Mark (2010) Post-translational events of a model reporter protein proceed with higher fidelity and accuracy upon mild hypothermic culturing of Chinese hamster ovary cells. Biotechnology and Bioengineering, 105 (1). pp. 215-220. ISSN 0006-3592. (doi:10.1002/bit.22533) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:22908)

McIntyre, J.J., Bull, Alan T., Bunch, Alan William (1996) Vancomycin production in batch and continuous culture. Biotechnology and Bioengineering, 49 (4). pp. 412-420. ISSN 0006-3592. (doi:10.1002/(SICI)1097-0290(19960220)49:4<412::AID-BIT8>3.0.CO;2-S) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:18679)

McIntyre, J.J., Bunch, Alan William, Bull, Alan T. (1999) Vancomycin production is enhanced in chemostat culture with biomass-recycle. Biotechnology and Bioengineering, 62 (5). pp. 576-582. ISSN 0006-3592. (doi:10.1002/(sici)1097-0290(19990305)62:5<576::aid-bit9>3.0.co;2-p) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:16930)

R

Reid, C.Q., Tait, Andrew S., Baldascini, H., Mohindra, A., Racher, Andrew J., Bilsborough, S., Smales, Christopher Mark, Hoare, Michael (2010) Rapid whole monoclonal antibody analysis by mass spectrometry: An Ultra scale-down study of the effect of harvesting by centrifugation on the post-translational modification profile. Biotechnology and Bioengineering, 107 (1). pp. 85-95. ISSN 0006-3592. (doi:10.1002/bit.22790) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:29225)

S

Smith, Sarah M., Walker, Kelly L., Jones, Alexander Stephen, Smith, Corinne J., Robinson, Colin (2019) Characterisation of a novel method for the production of single?span membrane proteins in Escherichia coli. Biotechnology and Bioengineering, 116 (4). pp. 722-733. ISSN 0006-3592. (doi:10.1002/bit.26895) (KAR id:70906)

Smales, Christopher Mark, Dinnis, Diane M., Stansfield, Scott H., Alete, Daniel E., Sage, E.A., Birch, John R., Racher, Andrew J., Marshall, Carol T., James, David C. (2004) Comparative proteomic analysis of GS-NSO murine myeloma cell lines with varying recombinant monoclonal antibody production rate. Biotechnology and Bioengineering, 88 (4). pp. 474-488. ISSN 0006-3592. (doi:10.1002/bit.20272) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:60)

Skrika-Alexopoulos, Eleftheria, Freedman, Robert B. (1993) Factors affecting enzyme characteristics of bilirubin oxidase suspensions in organic-solvents. Biotechnology and Bioengineering, 41 (9). pp. 887-893. ISSN 0006-3592. (doi:10.1002/bit.260410908) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:20684)

Smales, Christopher Mark, Pepper, Duncan S., James, David C. (2002) Protein modification during anti-viral heat-treatment bioprocessing of factor VIII concentrates, factor IX concentrates, and model proteins in the presence of sucrose. Biotechnology and Bioengineering, 77 (1). pp. 37-48. ISSN 0006-3592. (doi:10.1002/bit.10161) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:62)

Smales, Christopher Mark, Pepper, Duncan S., James, David C. (2000) Protein modification during antiviral heat bioprocessing. Biotechnology and Bioengineering, 67 (2). pp. 177-188. ISSN 0006-3592. (doi:10.1002/(SICI)1097-0290(20000120)67:2<177::AID-BIT7>3.0.CO;2-3) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6207)

Skrika-Alexopoulos, Eleftheria, Muir, Jacquelin, Freedman, Robert B. (1993) Stability of bilirubin oxidase in organic-solvent media - a comparative-study on 2 low-water systems. Biotechnology and Bioengineering, 41 (9). pp. 894-899. ISSN 0006-3592. (doi:10.1002/bit.260410909) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:20685)

T

Tait, Andrew S., Hogwood, Catherine E.M., Smales, Christopher Mark, Bracewell, Daniel G. (2011) Host cell protein dynamics in the supernatant of a mAb producing CHO cell line. Biotechnology and Bioengineering, 109 (4). pp. 971-982. ISSN 0006-3592. (doi:10.1002/bit.24383) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:29205)

U

Underhill, Michele F., Birch, John R., Smales, Christopher Mark, Naylor, Louise H. (2005) eIF2 alpha phosphorylation, stress perception, and the shutdown of global protein synthesis in cultured CHO cells. Biotechnology and Bioengineering, 89 (7). pp. 805-814. ISSN 0006-3592. (doi:10.1002/bit.20403) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:6220)

This list was generated on Thu Apr 25 23:22:46 2024 BST.