Items where Author, Editor or other role is "Brown, David"

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Number of items: 26.

A

Anthonyrajah, Erin Shamini (2018) Combined approaches to map protein-ligand interactions using NMR and X-ray crystallography. Doctor of Philosophy (PhD) thesis, University of Kent,. (KAR id:77160)

Adams, Paul D., Aertgeerts, Kathleen, Bauer, Cary, Bell, Jeffrey A., Berman, Helen M., Bhat, Talapady N., Blaney, Jeff M., Bolton, Evan, Bricogne, Gerard, Brown, David G., and others. (2016) Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop. Structure, 24 (4). pp. 502-508. ISSN 0969-2126. E-ISSN 1878-4186. (doi:10.1016/j.str.2016.02.017) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:60030)

B

Blaazer, Antoni R., Singh, Abhimanyu K., de Heuvel, Erik, Edink, Ewald, Orrling, Kristina M., Veerman, Johan J. N., van den Bergh, Toine, Jansen, Chimed, Balasubramaniam, Erin, Mooij, Wouter J., and others. (2018) Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity. Journal of Medicinal Chemistry, 61 (9). pp. 3870-3888. ISSN 0022-2623. (doi:10.1021/acs.jmedchem.7b01670) (KAR id:67365)

Bunnage, Mark E., Blagg, Julian, Steele, John, Owen, Dafydd R., Allerton, Charlotte M.N., McElroy, Andrew B., Miller, Duncan, Ringer, Tracy, Butcher, Ken, Beaumont, Kevin C., and others. (2007) Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. Journal of Medicinal Chemistry, 50 (24). pp. 6095-6103. ISSN 0022-2623. (doi:10.1021/jm0702433) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:34255)

C

Cowell, Alana R, Jacquemet, Guillaume, Singh, Abhimanyu K., Varela, Lorena, Nylund, Anna S, Ammon, York-Christoph, Brown, David G., Akhmanova, Anna, Ivaska, Johanna, Goult, Benjamin T and others. (2021) Talin rod domain–containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation. Journal of Cell Biology, 220 (9). Article Number e202005214. ISSN 0021-9525. (doi:10.1083/jcb.202005214) (KAR id:89331)

Cowell, Alana R, Jacquemet, Guillaume, Singh, Abhimanyu K., Ammon, York-Christoph, Brown, David G., Akhmanova, Anna, Ivaska, Johanna, Goult, Benjamin T (2020) Talin Rod Domain Containing Protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation. BioRxiv, . (doi:10.1101/2020.05.19.103606) (KAR id:81343)

D

de Heuvel, Erik, Singh, Abhimanyu K., Boronat, Pierre, Kooistra, Albert J., van der Meer, Tiffany, Sadek, Payman, Blaazer, Antoni R., Shaner, Nathan C., Bindels, Daphne S., Caljon, Guy, and others. (2019) Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2). Bioorganic & Medicinal Chemistry, 27 (18). pp. 4013-4029. ISSN 0968-0896. (doi:10.1016/j.bmc.2019.06.026) (KAR id:76976)

de Heuvel, Erik, Singh, Abhimanyu K., Edink, Ewald, van der Meer, Tiffany, van der Woude, Melanie, Sadek, Payman, Krell-Jørgensen, Mikkel P., van den Bergh, Toine, Veerman, Johan, Caljon, Guy, and others. (2019) Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors. Bioorganic & Medicinal Chemistry, . ISSN 0968-0896. (doi:10.1016/j.bmc.2019.06.027) (KAR id:75603)

Deery, Evelyne, Schroeder, Susanne, Lawrence, Andrew D., Taylor, Samantha L, Seyedarabi, Arefeh, Waterman, Jitka, Wilson, Keith S, Brown, David G., Geeves, Michael A., Howard, Mark J., and others. (2012) An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis. Nature Chemical Biology, 8 (11). pp. 933-940. ISSN 1552-4450. (doi:10.1038/nchembio.1086) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:31428)

F

Fish, Paul V., Barber, Christopher G., Brown, David G., Butt, Richard, Collis, Michael G., Dickinson, Roger P., Henry, Brian T., Horne, Valerie A., Huggins, John P., King, Elizabeth, and others. (2007) Selective Urokinase-Type Plasminogen Activator Inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. Journal of Medicinal Chemistry, 50 (10). pp. 2341-51. ISSN 0022-2623. (doi:10.1021/jm061066t) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:34256)

H

Huleani, Sergiu (2018) The identification of novel fragment leads by Biophysical methods for the inhibition of TbrPDEB1 as an anti-parasitic approach to Human African Trypanosomiasis. Master of Science by Research (MScRes) thesis, University of Kent,. (KAR id:71666)

Hughes, Samantha J., Millan, David S., Kilty, Iain C., Lewthwaite, Russell A., Mathias, John P., O’Reilly, Mark A., Pannifer, Andrew D., Phelan, Anne, Stühmeier, Frank, Baldock, Darren A., and others. (2011) Fragment based discovery of a novel and selective PI3 kinase inhibitor. Bioorganic & Medicinal Chemistry Letters, 21 (21). pp. 6586-6590. ISSN 0960-894X. (doi:10.1016/j.bmcl.2011.07.117) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:31350)

J

Jones, Alexander Stephen (2017) Proofreading of substrate by the Escherichia coli Twin Arginine Translocase. Doctor of Philosophy (PhD) thesis, University of Kent,. (KAR id:65666)

Jones, Peter, Storer, Ian, Sabnis, Yogesh A., Wakenhut, Florian M., Whitlock, Gavin A., England, Katherine S., Mukaiyama, Takasuke, Dehnhardt, Christoph M., Coe, Jotham W., Kortum, Steve W., and others. (2016) Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin. Journal of Medicinal Chemistry, 60 (2). pp. 767-786. ISSN 0022-2623. (doi:10.1021/acs.jmedchem.6b01634) (KAR id:60028)

L

Lawrence, Andrew D., Nemoto-Smith, Emi H, Deery, Evelyne, Baker, Joseph A., Schroeder, Susanne, Brown, David G., Tullet, Jennifer M.A., Howard, Mark J., Brown, Ian R., Smith, Alison G., and others. (2018) Construction of Fluorescent Analogs to Follow the Uptake and Distribution of Cobalamin (Vitamin B 12 ) in Bacteria, Worms, and Plants. Cell Chemical Biology, 25 (8). pp. 941-951. ISSN 2451-9456. (doi:10.1016/j.chembiol.2018.04.012) (KAR id:67083)

Luban, Jeremy, Blair, Wade S., Pickford, Chris, Irving, Stephen L., Brown, David G., Anderson, Marie, Bazin, Richard, Cao, Joan, Ciaramella, Giuseppe, Isaacson, Jason, and others. (2010) HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention. PLoS Pathogens, 6 (12). e1001220. ISSN 1553-7374. (doi:10.1371/journal.ppat.1001220) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:31353)

O

Owen, Dafydd R., Walker, John K., Jon Jacobsen, E., Freskos, John N., Hughes, Robert O., Brown, David L., Bell, Andrew S., Brown, David G., Phillips, Christopher, Mischke, Brent V., and others. (2009) Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors. Bioorganic & Medicinal Chemistry Letters, 19 (15). pp. 4088-4091. ISSN 0960-894X. (doi:10.1016/j.bmcl.2009.06.012) (KAR id:34240)

O'Brien, Sean E., Brown, David G., Mills, James E., Phillips, Chris, Morris, Gregg (2005) Computational Tools for the Analysis and Visualization of Multiple Protein-Ligand Complexes. Journal of Molecular Graphics and Modelling, 24 (3). pp. 186-194. ISSN 1093-3263. (doi:10.1016/j.jmgm.2005.08.003) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:34262)

P

Palmer, David J., Schroeder, Susanne, Lawrence, Andrew D., Deery, Evelyne, Lobo, Susana A., Saraiva, Ligia M., McLean, Kirsty J., Munro, Andrew W., Ferguson, Stuart J., Pickersgill, Richard W., and others. (2014) The structure, function and properties of sirohaem decarboxylase - an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway. Molecular Microbiology, 93 (2). pp. 247-261. ISSN 0950-382X. (doi:10.1111/mmi.12656) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:42020)

Phillips, Chris, Roberts, Lee R., Schade, Markus, Bazin, Richard, Bent, Andrew, Davies, Nichola L., Moore, Rob, Pannifer, Andrew D., Pickford, Andrew R., Prior, Stephen H., and others. (2011) Design and Structure of Stapled Peptides Binding to Estrogen Receptors. Journal of the American Chemical Society, 133 (25). pp. 9696-9699. ISSN 0002-7863. (doi:10.1021/ja202946k) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:31351)

Palmer, Michael J., Bell, Andrew S., Fox, David N.A., Brown, David G. (2007) Design of second generation phosphodiesterase 5 inhibitors. Current Topics in Medicinal Chemistry, 7 (4). pp. 405-419. ISSN 1568-0266. (doi:10.2174/156802607779941288) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:34251)

S

Salado, Irene G., Singh, Abhimanyu K., Moreno-Cinos, Carlos, Sakaine, Guna, Siderius, Marco, Van der Veken, Pieter, Matheeussen, An, van der Meer, Tiffany, Sadek, Payman, Gul, Sheraz, and others. (2020) Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds. Journal of Medicinal Chemistry, . ISSN 0022-2623. (doi:10.1021/acs.jmedchem.9b00985) (KAR id:80697)

Sijm, Maarten, Siciliano de Araújo, Julianna, Kunz, Stefan, Schroeder, Susanne, Edink, Ewald, Orrling, Kristina M., Matheeussen, An, van de Meer, Tiffany, Sadek, Payman, Custers, Hans, and others. (2019) Phenyldihydropyrazolones as Novel Lead Compounds Against Trypanosoma cruzi. ACS Omega, 4 (4). pp. 6585-6596. ISSN 2470-1343. (doi:10.1021/acsomega.8b02847) (KAR id:73804)

Skerratt, Sarah E., Andrews, Mark, Bagal, Sharan K., Bilsland, James, Brown, David, Bungay, Peter J., Cole, Susan, Gibson, Karl R, Jones, Russell, Morao, Inaki, and others. (2016) The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain. Journal of Medicinal Chemistry, 59 (22). pp. 10084-10099. ISSN 0022-2623. (doi:10.1021/acs.jmedchem.6b00850) (KAR id:59375)

W

Whitewood, Austin, Singh, Abhimanyu K, Brown, David G., Goult, Benjamin T (2018) Chlamydial virulence factor TarP mimics talin to disrupt the talin-vinculin complex. FEBS Letters, 592 (10). pp. 1751-1760. ISSN 0014-5793. (doi:10.1002/1873-3468.13074) (KAR id:66883)

Z

Zheng, Yang, Schroeder, Susanne, Kanev, Georgi K., Botros, Sanaa S., William, Samia, Sabra, Abdel-Nasser A., Maes, Louis, Caljon, Guy, Gil, Carmen, Martinez, Ana, and others. (2023) To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A? International Journal of Molecular Sciences, 24 (7). Article Number 6817. ISSN 1422-0067. (doi:10.3390/ijms24076817) (KAR id:100907)

This list was generated on Thu May 2 19:16:33 2024 BST.