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Construction of Fluorescent Analogs to Follow the Uptake and Distribution of Cobalamin (Vitamin B 12 ) in Bacteria, Worms, and Plants

Lawrence, Andrew D., Nemoto-Smith, Emi H, Deery, Evelyne, Baker, Joseph A., Schroeder, Susanne, Brown, David G., Tullet, Jennifer M.A., Howard, Mark J., Brown, Ian R., Smith, Alison G., and others. (2018) Construction of Fluorescent Analogs to Follow the Uptake and Distribution of Cobalamin (Vitamin B 12 ) in Bacteria, Worms, and Plants. Cell Chemical Biology, . ISSN 2451-9456. (doi:10.1016/j.chembiol.2018.04.012) (KAR id:67083)

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https://doi.org/10.1016/j.chembiol.2018.04.012

Abstract

Vitamin B12 is made by only certain prokaryotes yet is required by a number of eukaryotes

about how this nutrient is trafficked across the domains of life. Herein, we describe ways to

tetrapyrrole-derived ring. A further range of analogues were also constructed by attaching

complete and incomplete corrinoids to follow uptake in bacteria, worms and plants. By using

is able to acquire both cobyric acid and cobalamin analogues, that Caenorhabditis elegans

sativum are also able to transport B12.

Item Type: Article
DOI/Identification number: 10.1016/j.chembiol.2018.04.012
Uncontrolled keywords: vitamin B12; cobalamin; tetrapyrrole; biosynthesis; analogs; fluorescence; trafficking; Mycobacterium tuberculosis; Caenorhabditis elegans; higher plants
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Martin Warren
Date Deposited: 18 May 2018 09:20 UTC
Last Modified: 06 Feb 2020 04:18 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/67083 (The current URI for this page, for reference purposes)
Lawrence, Andrew D.: https://orcid.org/0000-0002-5853-5409
Brown, David G.: https://orcid.org/0000-0003-4605-4779
Tullet, Jennifer M.A.: https://orcid.org/0000-0002-2037-526X
Warren, Martin J.: https://orcid.org/0000-0002-6028-6456
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