Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors

Owen, Dafydd R. and Walker, John K. and Jon Jacobsen, E. and Freskos, John N. and Hughes, Robert O. and Brown, David L. and Bell, Andrew S. and Brown, David G. and Phillips, Christopher and Mischke, Brent V. and Molyneaux, John M. and Fobian, Yvette M. and Heasley, Steve E. and Moon, Joseph B. and Stallings, William C. and Joseph Rogier, D. and Fox, David N.A. and Palmer, Michael J. and Ringer, Tracy and Rodriquez-Lens, Margarita and Cubbage, Jerry W. and Blevis-Bal, Radhika M. and Benson, Alan G. and Acker, Brad A. and Maddux, Todd M. and Tollefson, Michael B. and Bond, Brian R. and MacInnes, Alan and Yu, Yung (2009) Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors. Bioorganic & Medicinal Chemistry Letters, 19 (15). pp. 4088-4091. ISSN 0960-894X. (doi:https://doi.org/10.1016/j.bmcl.2009.06.012) (Full text available)

Item Type: Article
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculties > Sciences > School of Biosciences
Faculties > Sciences > School of Biosciences > Protein Science Group
Faculties > Sciences > School of Biosciences > Biomedical Research Group
Depositing User: David Brown
Date Deposited: 11 Jun 2013 12:55 UTC
Last Modified: 22 Apr 2014 14:39 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/34240 (The current URI for this page, for reference purposes)
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