Skip to main content
Kent Academic Repository

Browse by Person (creator, editor, contributor, etc.)

Up a level
Export as [feed] Atom [feed] RSS 1.0 [feed] RSS 2.0
Group by: Item Type | Date | No Grouping
Number of items: 16.

2019

Sijm, Maarten and Siciliano de Araújo, Julianna and Kunz, Stefan and Schroeder, Susanne and Edink, Ewald and Orrling, Kristina M. and Matheeussen, An and van de Meer, Tiffany and Sadek, Payman and Custers, Hans and Cotillo, Ignacio and Martin, Julio J. and Siderius, Marco and Maes, Louis and Brown, David G. and de Nazaré Correia Soeiro, Maria and Sterk, GeertJan and de Esch, Iwan J.P. and Leurs, Rob (2019) Phenyldihydropyrazolones as Novel Lead Compounds Against Trypanosoma cruzi. ACS Omega, 4 (4). pp. 6585-6596. ISSN 2470-1343. (doi:https://doi.org/10.1021/acsomega.8b02847) (Full text available)
[img]
Preview

2018

Lawrence, Andrew D. and Nemoto-Smith, Emi H and Deery, Evelyne and Baker, Joseph A. and Schroeder, Susanne and Brown, David G. and Tullet, Jennifer M.A. and Howard, Mark J. and Brown, Ian R. and Smith, Alison G. and Boshoff, Helena I. and Barry, Clifton E. and Warren, Martin J. (2018) Construction of Fluorescent Analogs to Follow the Uptake and Distribution of Cobalamin (Vitamin B 12 ) in Bacteria, Worms, and Plants. Cell Chemical Biology, . ISSN 2451-9456. (doi:https://doi.org/10.1016/j.chembiol.2018.04.012) (Full text available)
[img]
Preview

Whitewood, Austin and Singh, Abhimanyu K and Brown, David G. and Goult, Benjamin T (2018) Chlamydial virulence factor TarP mimics talin to disrupt the talin-vinculin complex. FEBS Letters, 592 (10). pp. 1751-1760. ISSN 0014-5793. (doi:https://doi.org/10.1002/1873-3468.13074) (Full text available)
[img]
Preview
[img]
Preview

Blaazer, Antoni R. and Singh, Abhimanyu K. and de Heuvel, Erik and Edink, Ewald and Orrling, Kristina M. and Veerman, Johan J. N. and van den Bergh, Toine and Jansen, Chimed and Balasubramaniam, Erin and Mooij, Wouter J. and Custers, Hans and Sijm, Maarten and Tagoe, Daniel N. A. and Kalejaiye, Titilola D. and Munday, Jane C. and Tenor, Hermann and Matheeussen, An and Wijtmans, Maikel and Siderius, Marco and de Graaf, Chris and Maes, Louis and de Koning, Harry P. and Bailey, David S. and Sterk, Geert Jan and de Esch, Iwan J. P. and Brown, David G. and Leurs, Rob (2018) Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity. Journal of Medicinal Chemistry, 61 (9). pp. 3870-3888. ISSN 0022-2623. (doi:https://doi.org/10.1021/acs.jmedchem.7b01670) (Full text available)
[img]
Preview

2016

Jones, Peter and Storer, Ian and Sabnis, Yogesh A. and Wakenhut, Florian M. and Whitlock, Gavin A. and England, Katherine S. and Mukaiyama, Takasuke and Dehnhardt, Christoph M. and Coe, Jotham W. and Kortum, Steve W. and Chrencik, Jill E. and Brown, David G. and Jones, Rhys M. and Murphy, John R. and Yeoh, Thean and Morgan, Paul and Kilty, Iain (2016) Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin. Journal of Medicinal Chemistry, 60 (2). pp. 767-786. ISSN 0022-2623. (doi:https://doi.org/10.1021/acs.jmedchem.6b01634) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)
[img]

Adams, Paul D. and Aertgeerts, Kathleen and Bauer, Cary and Bell, Jeffrey A. and Berman, Helen M. and Bhat, Talapady N. and Blaney, Jeff M. and Bolton, Evan and Bricogne, Gerard and Brown, David G. and Burley, Stephen K. and Case, David A. and Clark, Kirk L. and Darden, Tom and Emsley, Paul and Feher, Victoria A. and Feng, Zukang and Groom, Colin R. and Harris, Seth F. and Hendle, Jorg and Holder, Thomas and Joachimiak, Andrzej and Kleywegt, Gerard J. and Krojer, Tobias and Marcotrigiano, Joseph and Mark, Alan E. and Markley, John L. and Miller, Matthew and Minor, Wladek and Montelione, Gaetano T. and Murshudov, Garib and Nakagawa, Atsushi and Nakamura, Haruki and Nicholls, Anthony and Nicklaus, Marc and Nolte, Robert T. and Padyana, Anil K. and Peishoff, Catherine E. and Pieniazek, Susan and Read, Randy J. and Shao, Chenghua and Sheriff, Steven and Smart, Oliver and Soisson, Stephen and Spurlino, John and Stouch, Terry and Svobodova, Radka and Tempel, Wolfram and Terwilliger, Thomas C. and Tronrud, Dale and Velankar, Sameer and Ward, Suzanna C. and Warren, Gregory L. and Westbrook, John D. and Williams, Pamela and Yang, Huanwang and Young, Jasmine (2016) Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop. Structure, 24 (4). pp. 502-508. ISSN 0969-2126. E-ISSN 1878-4186. (doi:https://doi.org/10.1016/j.str.2016.02.017) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)
[img]

2014

Palmer, David J. and Schroeder, Susanne and Lawrence, Andrew D. and Deery, Evelyne and Lobo, Susana A. and Saraiva, Ligia M. and McLean, Kirsty J. and Munro, Andrew W. and Ferguson, Stuart J. and Pickersgill, Richard W. and Brown, David G. and Warren, Martin J. (2014) The structure, function and properties of sirohaem decarboxylase - an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway. Molecular Microbiology, 93 (2). pp. 247-261. ISSN 0950-382X. (doi:https://doi.org/10.1111/mmi.12656) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

2012

Deery, Evelyne and Schroeder, Susanne and Lawrence, Andrew D. and Taylor, Samantha L and Seyedarabi, Arefeh and Waterman, Jitka and Wilson, Keith S and Brown, David G. and Geeves, Michael A. and Howard, Mark J. and Pickersgill, Richard W. and Warren, Martin J. (2012) An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis. Nature Chemical Biology, 8 (11). pp. 933-940. ISSN 1552-4450. (doi:https://doi.org/10.1038/nchembio.1086) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

2011

Hughes, Samantha J. and Millan, David S. and Kilty, Iain C. and Lewthwaite, Russell A. and Mathias, John P. and O’Reilly, Mark A. and Pannifer, Andrew D. and Phelan, Anne and Stühmeier, Frank and Baldock, Darren A. and Brown, David G. (2011) Fragment based discovery of a novel and selective PI3 kinase inhibitor. Bioorganic & Medicinal Chemistry Letters, 21 (21). pp. 6586-6590. ISSN 0960-894X. (doi:https://doi.org/10.1016/j.bmcl.2011.07.117) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

Phillips, Chris and Roberts, Lee R. and Schade, Markus and Bazin, Richard and Bent, Andrew and Davies, Nichola L. and Moore, Rob and Pannifer, Andrew D. and Pickford, Andrew R. and Prior, Stephen H. and Read, Christopher M. and Scott, Andrew and Brown, David G. and Xu, Bin and Irving, Stephen L. (2011) Design and Structure of Stapled Peptides Binding to Estrogen Receptors. Journal of the American Chemical Society, 133 (25). pp. 9696-9699. ISSN 0002-7863. (doi:https://doi.org/10.1021/ja202946k) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

2010

Luban, Jeremy and Blair, Wade S. and Pickford, Chris and Irving, Stephen L. and Brown, David G. and Anderson, Marie and Bazin, Richard and Cao, Joan and Ciaramella, Giuseppe and Isaacson, Jason and Jackson, Lynn and Hunt, Rachael and Kjerrstrom, Anne and Nieman, James A. and Patick, Amy K. and Perros, Manos and Scott, Andrew D. and Whitby, Kevin and Wu, Hua and Butler, Scott L. (2010) HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention. PLoS Pathogens, 6 (12). e1001220. ISSN 1553-7374. (doi:https://doi.org/10.1371/journal.ppat.1001220) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

2009

Owen, Dafydd R. and Walker, John K. and Jon Jacobsen, E. and Freskos, John N. and Hughes, Robert O. and Brown, David L. and Bell, Andrew S. and Brown, David G. and Phillips, Christopher and Mischke, Brent V. and Molyneaux, John M. and Fobian, Yvette M. and Heasley, Steve E. and Moon, Joseph B. and Stallings, William C. and Joseph Rogier, D. and Fox, David N.A. and Palmer, Michael J. and Ringer, Tracy and Rodriquez-Lens, Margarita and Cubbage, Jerry W. and Blevis-Bal, Radhika M. and Benson, Alan G. and Acker, Brad A. and Maddux, Todd M. and Tollefson, Michael B. and Bond, Brian R. and MacInnes, Alan and Yu, Yung (2009) Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors. Bioorganic & Medicinal Chemistry Letters, 19 (15). pp. 4088-4091. ISSN 0960-894X. (doi:https://doi.org/10.1016/j.bmcl.2009.06.012) (Full text available)
[img]
Preview

2007

Bunnage, Mark E. and Blagg, Julian and Steele, John and Owen, Dafydd R. and Allerton, Charlotte M.N. and McElroy, Andrew B. and Miller, Duncan and Ringer, Tracy and Butcher, Ken and Beaumont, Kevin C. and Evans, Karen and Gray, Andrew J. and Holland, Stephen J. and Feeder, Neil and Moore, Robert S. and Brown, David G. (2007) Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. Journal of Medicinal Chemistry, 50 (24). pp. 6095-6103. ISSN 0022-2623. (doi:https://doi.org/10.1021/jm0702433) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

Fish, Paul V. and Barber, Christopher G. and Brown, David G. and Butt, Richard and Collis, Michael G. and Dickinson, Roger P. and Henry, Brian T. and Horne, Valerie A. and Huggins, John P. and King, Elizabeth and O'Gara, Margaret and McCleverty, Dawn and McIntosh, Fraser and Phillips, Christopher and Webster, Robert (2007) Selective Urokinase-Type Plasminogen Activator Inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. Journal of Medicinal Chemistry, 50 (10). pp. 2341-51. ISSN 0022-2623. (doi:https://doi.org/10.1021/jm061066t) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

Palmer, Michael J. and Bell, Andrew S. and Fox, David N.A. and Brown, David G. (2007) Design of second generation phosphodiesterase 5 inhibitors. Current Topics in Medicinal Chemistry, 7 (4). pp. 405-419. ISSN 1568-0266. (doi:https://doi.org/10.2174/156802607779941288) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

2005

O'Brien, Sean E. and Brown, David G. and Mills, James E. and Phillips, Chris and Morris, Gregg (2005) Computational Tools for the Analysis and Visualization of Multiple Protein-Ligand Complexes. Journal of Molecular Graphics and Modelling, 24 (3). pp. 186-194. ISSN 1093-3263. (doi:https://doi.org/10.1016/j.jmgm.2005.08.003) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

This list was generated on Thu May 23 11:02:57 2019 BST.