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Solubility Prediction of Paracetamol in Water–Ethanol–Propylene Glycol Mixtures at 25 and 30 °C Using Practical Approaches

Jouyban, Abolghasem, Azarmir, Olduz, Mirzaei, Shahla, Hassanzadeh, Davoud, Ghafourian, Taravat, Acree, William Eugene, Nokhodchi, Ali (2008) Solubility Prediction of Paracetamol in Water–Ethanol–Propylene Glycol Mixtures at 25 and 30 °C Using Practical Approaches. Chemical and Pharmaceutical Bulletin, 56 (4). pp. 602-606. ISSN 0009-2363. (doi:10.1248/cpb.56.602) (KAR id:9979)

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Abstract

The solubility of paracetamol in water–ethanol–propylene glycol binary and ternary mixtures at 25 and

computational investigations and also was used to assess the prediction capability of the Jouyban–Acree model.

cosolvent concentration of 50% which is required in pharmaceutical formulations. The accuracy of the predicted

solubilities. The overall MPD of the Jouyban–Acree model and the log-linear model of Yalkowsky for the entire

for the predicted solubilities in mixtures having a cosolvent concentration of 50% were 12.09.1 and

22.011.0%.

Item Type: Article
DOI/Identification number: 10.1248/cpb.56.602
Uncontrolled keywords: paracetamol; binary solvent; ternary solvent; solubility prediction
Subjects: Q Science
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Taravat Ghafourian
Date Deposited: 15 Apr 2009 13:18 UTC
Last Modified: 28 May 2019 13:46 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/9979 (The current URI for this page, for reference purposes)

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