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Solubility Prediction of Paracetamol in Water–Ethanol–Propylene Glycol Mixtures at 25 and 30 °C Using Practical Approaches

Jouyban, Abolghasem, Azarmir, Olduz, Mirzaei, Shahla, Hassanzadeh, Davoud, Ghafourian, Taravat, Acree, William Eugene, Nokhodchi, Ali (2008) Solubility Prediction of Paracetamol in Water–Ethanol–Propylene Glycol Mixtures at 25 and 30 °C Using Practical Approaches. Chemical and Pharmaceutical Bulletin, 56 (4). pp. 602-606. ISSN 0009-2363. (doi:10.1248/cpb.56.602)

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Abstract

The solubility of paracetamol in water–ethanol–propylene glycol binary and ternary mixtures at 25 and 30 °C was determined using flask shake method. The generated data extended the solubility database for further computational investigations and also was used to assess the prediction capability of the Jouyban–Acree model. A new version of the model was proposed for modeling the solubility data in water–cosolvent mixtures with the cosolvent concentration of 50% which is required in pharmaceutical formulations. The accuracy of the predicted solubilities was evaluated by the mean percentage deviation (MPD) between the predicted and experimental solubilities. The overall MPD of the Jouyban–Acree model and the log-linear model of Yalkowsky for the entire composition range of the cosolvents were 11.08.7 and 55.417.8%, respectively; the corresponding values for the predicted solubilities in mixtures having a cosolvent concentration of 50% were 12.09.1 and 22.011.0%.

Item Type: Article
DOI/Identification number: 10.1248/cpb.56.602
Uncontrolled keywords: paracetamol; binary solvent; ternary solvent; solubility prediction
Subjects: Q Science
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Taravat Ghafourian
Date Deposited: 15 Apr 2009 13:18 UTC
Last Modified: 28 May 2019 13:46 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/9979 (The current URI for this page, for reference purposes)

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