Jouyban, Abolghasem, Azarmir, Olduz, Mirzaei, Shahla, Hassanzadeh, Davoud, Ghafourian, Taravat, Acree, William Eugene, Nokhodchi, Ali (2008) Solubility Prediction of Paracetamol in Water–Ethanol–Propylene Glycol Mixtures at 25 and 30 °C Using Practical Approaches. Chemical and Pharmaceutical Bulletin, 56 (4). pp. 602-606. ISSN 0009-2363. (doi:10.1248/cpb.56.602) (KAR id:9979)
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Official URL: http://dx.doi.org/10.1248/cpb.56.602 |
Abstract
The solubility of paracetamol in water–ethanol–propylene glycol binary and ternary mixtures at 25 and
30 °C was determined using flask shake method. The generated data extended the solubility database for further
computational investigations and also was used to assess the prediction capability of the Jouyban–Acree model.
A new version of the model was proposed for modeling the solubility data in water–cosolvent mixtures with the
cosolvent concentration of 50% which is required in pharmaceutical formulations. The accuracy of the predicted
solubilities was evaluated by the mean percentage deviation (MPD) between the predicted and experimental
solubilities. The overall MPD of the Jouyban–Acree model and the log-linear model of Yalkowsky for the entire
composition range of the cosolvents were 11.08.7 and 55.417.8%, respectively; the corresponding values
for the predicted solubilities in mixtures having a cosolvent concentration of 50% were 12.09.1 and
22.011.0%.
Item Type: | Article |
---|---|
DOI/Identification number: | 10.1248/cpb.56.602 |
Uncontrolled keywords: | paracetamol; binary solvent; ternary solvent; solubility prediction |
Subjects: | Q Science |
Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
Depositing User: | Taravat Ghafourian |
Date Deposited: | 15 Apr 2009 13:18 UTC |
Last Modified: | 16 Nov 2021 09:48 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/9979 (The current URI for this page, for reference purposes) |
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