Ghafourian, Taravat and Fooladi, Shadi (2001) The Effect of Structural QSAR Parameters on Skin Penetration. International Journal of Pharmaceutics, 217 (1-2). pp. 1-11. ISSN 0378-5173. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)
This is the latest version of this item.
|The full text of this publication is not available from this repository. (Contact us about this Publication)|
The permeability coefficients (log kp) of solutes through stratum corneum have been previously related to the octanol–water partition coefficients (log Poct) and solvatochromic parameters. In this study, permeation coefficient data are related to the theoretical chemistry-derived structural parameters and also molecular connectivity and molecular shape indices. The results show that these parameters are comparable with the solvatochromic parameters in correlation with log kp. Log Poct can be corrected by the theoretical parameters to explain permeation coefficients and the equilibrium distribution of compounds between the stratum corneum and water (log Km). Diffusion estimated from the expression log(D:h)log kplog Km, where D is the diffusion coefficient and h is the path length for diffusion was also analyzed successfully by the structural parameters.
Q Science > QD Chemistry
|Divisions:||Faculties > Science Technology and Medical Studies > Medway School of Pharmacy|
|Depositing User:||Taravat Ghafourian|
|Date Deposited:||06 Nov 2008 19:05|
|Last Modified:||20 May 2014 15:28|
|Resource URI:||https://kar.kent.ac.uk/id/eprint/10000 (The current URI for this page, for reference purposes)|
Available versions of this item
Solubility Prediction of Paracetamol in Water–Ethanol–Propylene Glycol
Mixtures at 25 and 30 °C Using Practical Approaches. (deposited 15 Apr 2009 13:18)
- The Effect of Structural QSAR Parameters on Skin Penetration. (deposited 06 Nov 2008 19:05) [Currently Displayed]