Solubility Prediction of Paracetamol in Water–Ethanol–Propylene Glycol Mixtures at 25 and 30 °C Using Practical Approaches

The solubility of paracetamol in water–ethanol–propylene glycol binary and ternary mixtures at 25 and

30 °C was determined using flask shake method. The generated data extended the solubility database for further

computational investigations and also was used to assess the prediction capability of the Jouyban–Acree model.

A new version of the model was proposed for modeling the solubility data in water–cosolvent mixtures with the

cosolvent concentration of 50% which is required in pharmaceutical formulations. The accuracy of the predicted

solubilities was evaluated by the mean percentage deviation (MPD) between the predicted and experimental

solubilities. The overall MPD of the Jouyban–Acree model and the log-linear model of Yalkowsky for the entire

composition range of the cosolvents were 11.08.7 and 55.417.8%, respectively; the corresponding values

for the predicted solubilities in mixtures having a cosolvent concentration of 50% were 12.09.1 and

22.011.0%.