Genomic resources and tools to investigate factors associated with chondrodystrophy in California condors

The California condor is among the endangered avian species under captive management for which genetic and genomic investigation technologies are being developed. A genetic form of chondrodystrophy in condors was previously identified that appears to be inherited as an autosomal recessive allele. The ongoing research project is aimed at (i) initiating development of a genetic map of the California condor, (ii) evaluating the candidate genes responsible for heritable chondrodystrophy, and (iii) producing a carrier test for individuals possessing the gene. To address genome research and genetic management of California condors, we have begun to develop genetic, cytogenetic and comparative maps as a prerequisite for identification of candidate loci for the chondrodystrophy mutation. We produced a highly redundant California condor genomic BAC library that was used to construct a first-generation chicken-condor comparative physical map and to identify specific condor BACs carrying candidate genes for chondrodystrophy. Sequencing and characterization of candidate loci are underway that will enable us to identify carriers of the chondrodystrophy allele and provide tools for improved genetic management of this disease.