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RCT trial of diet treatment for adults with untreated PKU

Amos, Allayne, Murphy, Glynis H. (2008) RCT trial of diet treatment for adults with untreated PKU. In: Journal of Intellectual Disability Research. 52 (8-9). p. 665. Wiley (doi:10.1111/j.1365-2788.2008.01085.x) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
http://dx.doi.org/10.1111/j.1365-2788.2008.01085.x

Abstract

Aim: Phenylketonuria (PKU) is a congenital metabolic disorder that, unless treated with a special low-phenylalanine (low-phe) diet from infancy, leads to severe intellectual disabilities. The aim of this study was to test the efficacy of the low-phe diet for adults with untreated PKU.

Method: 36 adults with untreated PKU were recruited into a double-blind randomized controlled crossover trial. Measures included weekly blood phenylalanine levels, daily behavioural records, and, at the end of each phase, standardized measures of skills and behavioursand direct observations.

Results: Blood phenylalanine levels were well controlled by the low-phe diet but there were no associated significant changes in challenging behaviours. However, people who had the low-phe diet first were significantly more likely to withdraw (chi-squared, p<0.01). Also carers made more positive comments at the end of the low-phe diet phase than at the end of other phases (chi-squared, p<0.001).

Conclusions: Carers’ responses suggest detectable improvements in the behaviour of adults with PKU when treated with low-phe diet, but this is not supported by quantitative analysis

Item Type: Conference or workshop item (Paper)
DOI/Identification number: 10.1111/j.1365-2788.2008.01085.x
Additional information: Meeting Abstract
Subjects: R Medicine > RC Internal medicine > RC321 Neuroscience. Biological psychiatry. Neuropsychiatry
L Education
Divisions: Faculties > Social Sciences > School of Social Policy Sociology and Social Research > Tizard
Depositing User: Suzanne Duffy
Date Deposited: 05 Feb 2009 11:51 UTC
Last Modified: 07 Feb 2020 04:02 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/14796 (The current URI for this page, for reference purposes)
Murphy, Glynis H.: https://orcid.org/0000-0001-7817-5861
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