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A Drug release study from hydroxypropylmethylcellulose (HPMC) matrices using QSPR modeling

Ghafourian, Taravat, Safari, Arezoo, Parviz, Fatemah, Adibkia, Khosro, Nokhodchi, Ali (2007) A Drug release study from hydroxypropylmethylcellulose (HPMC) matrices using QSPR modeling. Journal of Pharmaceutical Sciences, 96 (12). pp. 3334-3351. ISSN 0022-3549. (doi:10.1002/jps.20990) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:9996)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1002/jps.20990

Abstract

This investigation is aimed at characterization of the mode of release from two different substitution types of HPMC and the effect of chemical structure of drugs using the QSPR (Quantitative - Structure Property Relationship) technique. To this end, release profiles of HPMC matrices of several drugs containing the same formulation and compressed at a constant pressure were studied. QSPR method was used to establish statistically significant

relationships between release parameters and the structural descriptors. Structural descriptors consisted of molecular mechanical, quantum mechanical and graph-theoretical parameters, as well as the partition coefficient and the aqueous solubility of the drugs. The results showed that the most important factors determining the release profile from both HPMC K4M and HPMC E4M matrices were the aqueous solubility of drugs (which could be substituted efficiently by dipole moment) and the size of the drug molecules. Comparison of drug release from matrices prepared using the two grades of HPMC showed very distinct differences for some drugs, as evaluated by the similarity factor. The results indicated that the source of the difference could be sought in the drug properties (as exemplified by the aqueous solubility and surface area) as well as the rate of erosion (that depends mainly on the polymer type).

Item Type: Article
DOI/Identification number: 10.1002/jps.20990
Uncontrolled keywords: matrix; release rate; HPMC; QSAR; QSPR
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Ali Nokhodchi
Date Deposited: 14 Jul 2008 11:12 UTC
Last Modified: 05 Nov 2024 09:43 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/9996 (The current URI for this page, for reference purposes)

University of Kent Author Information

Ghafourian, Taravat.

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Nokhodchi, Ali.

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