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Features of fractal conformity and bioconsolidation in the early myogenesis gene expression and their relationship to the genetic diversity of chicken breeds

Kochish, Ivan I., Brazhnik, Evgeni A., Vorobyov, N.I., Nikonov, I N, Korenyuga, M V, Myasnikova, O V, Griffin, Darren K., Surai, Peter F., Romanov, Michael N (2023) Features of fractal conformity and bioconsolidation in the early myogenesis gene expression and their relationship to the genetic diversity of chicken breeds. Animals, 13 (3). Article Number 521. ISSN 2076-2615. E-ISSN 2076-2615. (doi:10.3390/ani13030521) (KAR id:99855)


Simple Summary

In the bodies of animals, including birds, gene expression leads to the synthesis of many proteins. To provide optimal cellular and organismal properties and functions, many genes should work in concert, reaching certain balanced relationships (or networks) between them and the intensities of their expression. Here, we studied the expression of several genes responsible for muscle formation and growth in chick embryos of diverse breeds belonging to various utility types. Using two mathematical (fractal) models and the respective indices, we showed that there are specific coordinated patterns of gene expression in the embryonic breast and thigh muscles. These patterns correlated with growth rate of chicks after hatching and depended on a utility type of the breeds studied. Overall, the proposed models contributed to an expanded understanding of the coordinated gene expression in early development and growth, providing additional characteristics of genetic diversity in chickens.


Elements of fractal analysis are widely used in scientific research, including several biological disciplines. In this study, we hypothesized that chicken breed biodiversity manifests not only at the phenotypic level, but also at the genetic-system level in terms of different profiles of fractal conformity and bioconsolidation in the early myogenesis gene expression. To demonstrate this effect, we developed two mathematical models that describe the fractal nature of the expression of seven key genes in the embryonic breast and thigh muscles in eight breeds of meat, dual purpose, egg and game types. In the first model, we produced breed-specific coefficients of gene expression conformity in each muscle type using the slopes of regression dependencies, as well as an integral myogenesis gene expression index (MGEI). Additionally, breed fractal dimensions and integral myogenesis gene expression fractal dimension index (MGEFDI) were determined. The second gene expression model was based on plotting fractal portraits and calculating indices of fractal bioconsolidation. The bioconsolidation index of myogenesis gene expression correlated with the chick growth rate and nitric oxide (NO) oxidation rate. The proposed fractal models were instrumental in interpreting the genetic diversity of chickens at the level of gene expression for early myogenesis, NO metabolism and the postnatal growth of chicks.

Item Type: Article
DOI/Identification number: 10.3390/ani13030521
Uncontrolled keywords: chicken breeds; gene expression; myogenesis; genetic diversity; mathematical modelling; fractal analysis; bioconsolidation index
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QH Natural history > QH75 Conservation (Biology)
Q Science > QP Physiology (Living systems)
S Agriculture > SF Animal culture
Divisions: Divisions > Division of Natural Sciences > Centre for Interdisciplinary Studies of Reproduction
Divisions > Division of Natural Sciences > Biosciences
Signature Themes: Food Systems, Natural Resources and Environment
Depositing User: Mike Romanov
Date Deposited: 01 Feb 2023 16:49 UTC
Last Modified: 08 Sep 2023 13:04 UTC
Resource URI: (The current URI for this page, for reference purposes)

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