Architecture-controlled release of ibuprofen from polymeric nanoparticles

Shehata, Sara, Serpell, Christopher J., Biagini, Stefano (2020) Architecture-controlled release of ibuprofen from polymeric nanoparticles. Materials Today Communications, 25 . Article Number 101562. ISSN 2352-4928. (doi:10.1016/j.mtcomm.2020.101562) (KAR id:99734)

PDF Author's Accepted Manuscript Language: English DOI for this version: 10.22024/UniKent/01.02.99734.3359013 This work is licensed under a Creative Commons Attribution 4.0 International License.
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Official URL: https://doi.org/10.1016/j.mtcomm.2020.101562

Abstract

Smart polymeric systems are required that are able to release a therapeutic drug with control over timing and location of delivery. Herein we have investigated the architecture-controlled and pH-triggered release of ibuprofen from a polymeric nanoparticle system prepared using ring-opening metathesis polymerisation. The co-polymerisation of norbornene-derived ibuprofen (NB-Ibu) and poly(ethylene glycol) (NB-PEG) monomers produced polymers with block and random sequence architectures. Self-assembly into nanoparticle systems and release of ibuprofen only under basic conditions was shown to be controlled by polymer sequence.

Item Type:	Article
DOI/Identification number:	10.1016/j.mtcomm.2020.101562
Additional information:	For the purpose of open access, the author has applied a CC BY public copyright licence (where permitted by UKRI, an Open Government Licence or CC BY ND public copyright licence may be used instead) to any Author Accepted Manuscript version arising.
Subjects:	Q Science Q Science > QD Chemistry
Divisions:	Divisions > Division of Natural Sciences > Chemistry and Forensics
Funders:	Engineering and Physical Sciences Research Council (https://ror.org/0439y7842) University of Kent (https://ror.org/00xkeyj56)
Depositing User:	Stefano Biagini
Date Deposited:	27 Jan 2023 14:27 UTC
Last Modified:	30 Jan 2023 10:41 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/99734 (The current URI for this page, for reference purposes)
Shehata, Sara:	https://orcid.org/0000-0002-7663-5550
Serpell, Christopher J.:	https://orcid.org/0000-0002-2848-9077
Biagini, Stefano:	https://orcid.org/0000-0002-4713-5127

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