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Architecture-controlled release of ibuprofen from polymeric nanoparticles

Shehata, Sara, Serpell, Christopher J., Biagini, Stefano (2020) Architecture-controlled release of ibuprofen from polymeric nanoparticles. Materials Today Communications, 25 . Article Number 101562. ISSN 2352-4928. (doi:10.1016/j.mtcomm.2020.101562) (KAR id:99734)

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Language: English

DOI for this version: 10.22024/UniKent/01.02.99734.3359013

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Smart polymeric systems are required that are able to release a therapeutic drug with control over timing and location of delivery. Herein we have investigated the architecture-controlled and pH-triggered release of ibuprofen from a polymeric nanoparticle system prepared using ring-opening metathesis polymerisation. The co-polymerisation of norbornene-derived ibuprofen (NB-Ibu) and poly(ethylene glycol) (NB-PEG) monomers produced polymers with block and random sequence architectures. Self-assembly into nanoparticle systems and release of ibuprofen only under basic conditions was shown to be controlled by polymer sequence.

Item Type: Article
DOI/Identification number: 10.1016/j.mtcomm.2020.101562
Additional information: For the purpose of open access, the author has applied a CC BY public copyright licence (where permitted by UKRI, an Open Government Licence or CC BY ND public copyright licence may be used instead) to any Author Accepted Manuscript version arising.
Subjects: Q Science
Q Science > QD Chemistry
Divisions: Divisions > Division of Natural Sciences > Chemistry and Forensics
Funders: Engineering and Physical Sciences Research Council (
University of Kent (
Depositing User: Stefano Biagini
Date Deposited: 27 Jan 2023 14:27 UTC
Last Modified: 30 Jan 2023 10:41 UTC
Resource URI: (The current URI for this page, for reference purposes)
Shehata, Sara:
Serpell, Christopher J.:
Biagini, Stefano:
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