Shehata, Sara, Serpell, Christopher J., Biagini, Stefano (2020) Architecture-controlled release of ibuprofen from polymeric nanoparticles. Materials Today Communications, 25 . Article Number 101562. ISSN 2352-4928. (doi:10.1016/j.mtcomm.2020.101562) (KAR id:99734)
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Author's Accepted Manuscript
Language: English DOI for this version: 10.22024/UniKent/01.02.99734.3359013 
This work is licensed under a Creative Commons Attribution 4.0 International License.
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| Official URL: https://doi.org/10.1016/j.mtcomm.2020.101562 |
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Abstract
Smart polymeric systems are required that are able to release a therapeutic drug with control over timing and location of delivery. Herein we have investigated the architecture-controlled and pH-triggered release of ibuprofen from a polymeric nanoparticle system prepared using ring-opening metathesis polymerisation. The co-polymerisation of norbornene-derived ibuprofen (NB-Ibu) and poly(ethylene glycol) (NB-PEG) monomers produced polymers with block and random sequence architectures. Self-assembly into nanoparticle systems and release of ibuprofen only under basic conditions was shown to be controlled by polymer sequence.
| Item Type: | Article |
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| DOI/Identification number: | 10.1016/j.mtcomm.2020.101562 |
| Additional information: | For the purpose of open access, the author has applied a CC BY public copyright licence (where permitted by UKRI, an Open Government Licence or CC BY ND public copyright licence may be used instead) to any Author Accepted Manuscript version arising. |
| Subjects: |
Q Science Q Science > QD Chemistry |
| Institutional Unit: | Schools > School of Natural Sciences > Chemistry and Forensic Science |
| Former Institutional Unit: |
Divisions > Division of Natural Sciences > Chemistry and Forensics
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| Funders: |
Engineering and Physical Sciences Research Council (https://ror.org/0439y7842)
University of Kent (https://ror.org/00xkeyj56) |
| Depositing User: | Stefano Biagini |
| Date Deposited: | 27 Jan 2023 14:27 UTC |
| Last Modified: | 22 Jul 2025 09:14 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/99734 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Shehata, Sara.
| Creator's ORCID: |
 https://orcid.org/0000-0002-7663-5550
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| CReDIT Contributor Roles: |
Serpell, Christopher J..
| Creator's ORCID: |
https://orcid.org/0000-0002-2848-9077
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| CReDIT Contributor Roles: |
Biagini, Stefano.
| Creator's ORCID: |
https://orcid.org/0000-0002-4713-5127
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| CReDIT Contributor Roles: |
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