The Discovery of Imine Reductases and their Utilisation for the Synthesis of Tetrahydroisoquinolines

Cárdenas‐Fernández, Max, Roddan, Rebecca, Carter, Eve M., Hailes, Helen C., Ward, John M. (2023) The Discovery of Imine Reductases and their Utilisation for the Synthesis of Tetrahydroisoquinolines. ChemCatChem, 15 (3). Article Number e202201126. ISSN 1867-3899. (doi:10.1002/cctc.202201126) (KAR id:99613)

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Official URL: https://doi.org/10.1002/cctc.202201126

Abstract

Imine reductases (IREDs) are NADPH-dependent enzymes with significant biocatalytic potential for the synthesis of primary, secondary, and tertiary chiral amines. Their applications include the reduction of cyclic imines and the reductive amination of prochiral ketones. In this study, twenty-nine novel IREDs were revealed through genome mining. Imine reductase activities were screened at pH 7 and 9 and in presence of either NADPH or NADH

Item Type:	Article
DOI/Identification number:	10.1002/cctc.202201126
Additional information:	For the purpose of open access, the author(s) has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising.
Uncontrolled keywords:	Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Catalysis
Subjects:	Q Science > QH Natural history > QH301 Biology T Technology
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Funders:	Biotechnology and Biological Sciences Research Council (https://ror.org/00cwqg982) Birkbeck, University of London (https://ror.org/02mb95055) Engineering and Physical Sciences Research Council (https://ror.org/0439y7842)
SWORD Depositor:	JISC Publications Router
Depositing User:	JISC Publications Router
Date Deposited:	25 Jan 2023 15:18 UTC
Last Modified:	20 Nov 2023 15:38 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/99613 (The current URI for this page, for reference purposes)

University of Kent Author Information

Cárdenas‐Fernández, Max.

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