Kumar, Rahul, Aktay-Cetin, Öznur, Craddock, Vaughn, Morales-Cano, Daniel, Kosanovic, Djuro, Cogolludo, Angel, Perez-Vizcaino, Francisco, Avdeev, Sergey, Kumar, Ashok, Ram, Anil Kumar, and others. (2023) Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities. PLOS Pathogens, 19 (1). Article Number e1011063. ISSN 1553-7366. E-ISSN 1553-7374. (doi:10.1371/journal.ppat.1011063) (KAR id:99502)
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| Official URL: https://doi.org/10.1371/journal.ppat.1011063 |
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Abstract
The Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its sublineages pose a new challenge to healthcare systems worldwide due to its ability to efficiently spread in immunized populations and its resistance to currently available therapies. COVID-19, although targeting primarily the respiratory system, is also now well established that later affects every organ in the body. Most importantly, despite the available therapy and vaccine-elicited protection, the long-term consequences of viral infection in breakthrough and asymptomatic individuals are areas of concern. In the past two years, investigators accumulated evidence on how the virus triggers our immune system and the molecular signals involved in the cross-talk between immune cells and structural cells in the pulmonary vasculature to drive pathological lung complications such as endothelial dysfunction and thrombosis. In the review, we emphasize recent updates on the pathophysiological inflammatory and immune responses associated with SARS-CoV-2 infection and their potential long-term consequences that may consequently lead to the development of pulmonary vascular diseases.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1371/journal.ppat.1011063 |
| Uncontrolled keywords: | Review, Medicine and health sciences, Biology and life sciences |
| Subjects: | R Medicine |
| Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
| SWORD Depositor: | JISC Publications Router |
| Depositing User: | JISC Publications Router |
| Date Deposited: | 16 Jan 2023 10:05 UTC |
| Last Modified: | 03 Feb 2023 16:09 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/99502 (The current URI for this page, for reference purposes) |
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