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Novel molecular classification of colorectal cancer and correlation with long-term survival

Mangi, Fayaz Hussain, Shaikh, Tanweer Ahmed, Soria, Daniele, Qureshi, Jawaid Naeem, Ujjan, Ikram Uddin, Syed, Binafsha Manzoor (2021) Novel molecular classification of colorectal cancer and correlation with long-term survival. Journal Of Clinical Oncology, 39 (15supp). Article Number e15514. ISSN 0732-183X. (doi:10.1200/JCO.2021.39.15_suppl.e15514) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:99030)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL:
https://doi.org/10.1200/JCO.2021.39.15_suppl.e1551...

Abstract

Background: Colorectal cancer (CRC) is a heterogeneous disease, however there is limited information available regarding molecular classification and correlation with long term clinical outcome. Methods: Over the period of 11 years (2008 to 2018) totals 435 patients of colorectal cancer were reported and their tumour blocks and complete set of clinical information was available for 201 patients. Immunohistochemistry was done for ER, PR, HER 2-neu, Ki-67, Bcl-2, E-Cadherin, P53, CEA, EGFR, and VEGF. PDL1, CDX-2 and CK 20. The biological pattern characterized by partitioned clustering method as described using R software. Survival analysis was done by using Kaplan Meier method. Results: There were 201 patients including 54.7% male and females were 45.3 %. Median survival was 28 months. Cluster analysis showed four novel clusters (Table), with major difference based on Ki67, CDX2 and p53. These classes showed difference in median survival, where common class 1 showed higher survival while common cluster 4 showed poor survival. Conclusions: There are at least four distinct molecular classes of colorectal cancer which can be potentially utilized in clinical practice. Pattern of Novel molecular classification of colorectal cancer and correlation with long term survival.

Item Type: Article
DOI/Identification number: 10.1200/JCO.2021.39.15_suppl.e15514
Subjects: R Medicine
Divisions: Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Computing
Depositing User: Daniel Soria
Date Deposited: 09 Dec 2022 13:03 UTC
Last Modified: 12 Dec 2022 10:45 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/99030 (The current URI for this page, for reference purposes)

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