Chung, Cheuk To, Lee, Sharen, Zhou, Jiandong, Chou, Oscar Hou In, Lee, Teddy Tai Loy, Leung, Keith Sai Kit, Jeevaratnam, Kamalan, Wong, Wing Tak, Liu, Tong, Tse, Gary and others. (2022) Clinical characteristics, genetic basis and healthcare resource utilisation and costs in patients with catecholaminergic polymorphic ventricular tachycardia: A retrospective cohort study. Reviews in Cardiovascular Medicine, 23 (8). p. 276. ISSN 1530-6550. E-ISSN 2153-8174. (doi:10.31083/j.rcm2308276) (KAR id:98709)
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Official URL: https://doi.org/10.31083/j.rcm2308276 |
Abstract
Background:
This study examined the clinical characteristics, genetic basis, healthcare utilisation and costs of catecholaminergic ventricular tachycardia (CPVT) patients from a Chinese city.
Methods:
This was a territory-wide retrospective cohort study of consecutive CPVT patients at public hospitals or clinics in Hong Kong. Healthcare resource utilisation for accident and emergency (A&E), inpatient and outpatient attendances were analysed over 19 years (2001–2019) followed by calculations of annualised costs (in USD).
Results:
Sixteen patients with a median presentation age (interquartile range (IQR) of 11 (9–14) years old) were included. Fifteen patients (93.8%) were initially symptomatic. Ten patients had both premature ventricular complexes (PVCs) and ventricular tachycardia/fibrillation (VT/VF). One patient had PVCs without VT/VF. Genetic tests were performed on 14 patients (87.5%). Eight (57.1%) tested positive for the ryanodine receptor 2 (RyR2) gene. Seven variants have been described elsewhere (c.14848G>A, c.12475C>A, c.7420A
>G, c.11836G>A, c.14159T>C, c.10046C> T and c.7202G>A). c.14861C>G is a novel RyR2 variant not been reported outside this cohort. Patients were treated with beta-blockers (n = 16), amiodarone (n = 3) and verapamil (n = 2). Sympathectomy (n = 8) and implantable-cardioverter defibrillator implantation (n = 3) were performed. Over a median follow-up of 13.3 years (IQR: 8.4–18.1) years, six patients exhibited incident VT/VF. At the patient level, the median (IQR) annualised costs for A&E, inpatient and outpatient attendances were $66 (40–95), $10521 (5240–66887) and $791 (546–1105), respectively. Conclusions:
All patients presented before the age of 19. The yield of genetic testing was 57%. The most expensive attendance type was inpatient stays, followed by outpatients and A&E attendances.
Item Type: | Article |
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DOI/Identification number: | 10.31083/j.rcm2308276 |
Uncontrolled keywords: | CPVT; HCRU; tachycardia; genetics |
Subjects: | R Medicine > R Medicine (General) |
Divisions: | Divisions > Division of Natural Sciences > Kent and Medway Medical School |
Funders: | University of Kent (https://ror.org/00xkeyj56) |
Depositing User: | Manfred Gschwandtner |
Date Deposited: | 05 Dec 2022 18:17 UTC |
Last Modified: | 05 Nov 2024 13:04 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/98709 (The current URI for this page, for reference purposes) |
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