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A Reversibly Porous Supramolecular Peptide Framework

Brightwell, D, Truccolo, G., Samanta, K, Fenn, Elliott James, Holder, Simon J., Shepherd, H.J., Hawes, C, Palma, Aniello (2022) A Reversibly Porous Supramolecular Peptide Framework. Chemistry - A European Journal, 28 (66). Article Number e202202368. ISSN 0947-6539. E-ISSN 1521-3765. (doi:10.1002/chem.202202368) (KAR id:98647)

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The ability to use bio-inspired building blocks in the assembly of novel supramolecular frameworks is at the forefront of an exciting research field. Herein, we present the first polyproline helix to self-assemble into a reversibly porous, crystalline, supramolecular peptide framework (SPF). This framework is assembled from a short oligoproline, adopting the polyproline II conformation, driven by hydrogen-bonding and dispersion interactions. Thermal activation, guest-induced dynamic porosity and enantioselective guest inclusion have been demonstrated for this novel system. The principles of the self-assembly associated with this SPF will be used as a blueprint allowing for the further development of helical peptide linkers in the rational design of SPFs and metal-peptide frameworks.

Item Type: Article
DOI/Identification number: 10.1002/chem.202202368
Uncontrolled keywords: General Chemistry, Catalysis, Organic Chemistry
Subjects: Q Science > QD Chemistry
Divisions: Divisions > Division of Natural Sciences > Chemistry and Forensics
Funders: [18] EPSRC
Royal Society of Chemistry (
Depositing User: Aniello Palma
Date Deposited: 02 Dec 2022 14:38 UTC
Last Modified: 17 Feb 2023 14:37 UTC
Resource URI: (The current URI for this page, for reference purposes)
Samanta, K:
Holder, Simon J.:
Shepherd, H.J.:
Palma, Aniello:
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