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A Reversibly Porous Supramolecular Peptide Framework

Brightwell, Dominic F., Truccolo, Giada, Samanta, Kushal, Fenn, Elliott James, Holder, Simon J., Shepherd, Helena J., Hawes, Chris, Palma, Aniello (2022) A Reversibly Porous Supramolecular Peptide Framework. Chemistry - A European Journal, 28 (66). Article Number e202202368. ISSN 0947-6539. E-ISSN 1521-3765. (doi:10.1002/chem.202202368) (KAR id:98647)

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The ability to use bio-inspired building blocks in the assembly of novel supramolecular frameworks is at the forefront of an exciting research field. Herein, we present the first polyproline helix to self-assemble into a reversibly porous, crystalline, supramolecular peptide framework (SPF). This framework is assembled from a short oligoproline, adopting the polyproline II conformation, driven by hydrogen-bonding and dispersion interactions. Thermal activation, guest-induced dynamic porosity and enantioselective guest inclusion have been demonstrated for this novel system. The principles of the self-assembly associated with this SPF will be used as a blueprint allowing for the further development of helical peptide linkers in the rational design of SPFs and metal-peptide frameworks.

Item Type: Article
DOI/Identification number: 10.1002/chem.202202368
Additional information: For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
Uncontrolled keywords: General Chemistry, Catalysis, Organic Chemistry
Subjects: Q Science > QD Chemistry
Divisions: Divisions > Division of Natural Sciences > Chemistry and Forensics
Funders: Engineering and Physical Sciences Research Council (
Royal Society of Chemistry (
Depositing User: Aniello Palma
Date Deposited: 02 Dec 2022 14:38 UTC
Last Modified: 27 Feb 2024 11:19 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Brightwell, Dominic F..

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Truccolo, Giada.

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Samanta, Kushal.

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Fenn, Elliott James.

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Holder, Simon J..

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Shepherd, Helena J..

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Palma, Aniello.

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