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A Reversibly Porous Supramolecular Peptide Framework

Brightwell, Dominic F., Truccolo, Giada, Samanta, Kushal, Fenn, Elliott James, Holder, Simon J., Shepherd, Helena J., Hawes, Chris, Palma, Aniello (2022) A Reversibly Porous Supramolecular Peptide Framework. Chemistry - A European Journal, 28 (66). Article Number e202202368. ISSN 0947-6539. E-ISSN 1521-3765. (doi:10.1002/chem.202202368) (KAR id:98647)

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Abstract

The ability to use bio-inspired building blocks in the assembly of novel supramolecular frameworks is at the forefront of an exciting research field. Herein, we present the first polyproline helix to self-assemble into a reversibly porous, crystalline, supramolecular peptide framework (SPF). This framework is assembled from a short oligoproline, adopting the polyproline II conformation, driven by hydrogen-bonding and dispersion interactions. Thermal activation, guest-induced dynamic porosity and enantioselective guest inclusion have been demonstrated for this novel system. The principles of the self-assembly associated with this SPF will be used as a blueprint allowing for the further development of helical peptide linkers in the rational design of SPFs and metal-peptide frameworks.

Item Type: Article
DOI/Identification number: 10.1002/chem.202202368
Additional information: For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
Uncontrolled keywords: General Chemistry, Catalysis, Organic Chemistry
Subjects: Q Science > QD Chemistry
Divisions: Divisions > Division of Natural Sciences > Chemistry and Forensics
Funders: Engineering and Physical Sciences Research Council (https://ror.org/0439y7842)
Royal Society of Chemistry (https://ror.org/025sbr097)
Depositing User: Aniello Palma
Date Deposited: 02 Dec 2022 14:38 UTC
Last Modified: 27 Feb 2024 11:19 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/98647 (The current URI for this page, for reference purposes)

University of Kent Author Information

Brightwell, Dominic F..

Creator's ORCID: https://orcid.org/0000-0001-7699-9795
CReDIT Contributor Roles:

Truccolo, Giada.

Creator's ORCID:
CReDIT Contributor Roles:

Samanta, Kushal.

Creator's ORCID: https://orcid.org/0000-0002-7414-4475
CReDIT Contributor Roles:

Fenn, Elliott James.

Creator's ORCID:
CReDIT Contributor Roles:

Holder, Simon J..

Creator's ORCID: https://orcid.org/0000-0001-8977-9257
CReDIT Contributor Roles:

Shepherd, Helena J..

Creator's ORCID: https://orcid.org/0000-0003-0832-4475
CReDIT Contributor Roles:

Palma, Aniello.

Creator's ORCID: https://orcid.org/0000-0001-9626-4390
CReDIT Contributor Roles:
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