Brightwell, Dominic F., Truccolo, Giada, Samanta, Kushal, Fenn, Elliott James, Holder, Simon J., Shepherd, Helena J., Hawes, Chris, Palma, Aniello (2022) A Reversibly Porous Supramolecular Peptide Framework. Chemistry - A European Journal, 28 (66). Article Number e202202368. ISSN 0947-6539. E-ISSN 1521-3765. (doi:10.1002/chem.202202368) (KAR id:98647)
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Official URL: https://doi.org/10.1002/chem.202202368 |
Resource title: | Engineered Polyproline Helices for the Rational Design of Supramolecular Constructs |
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Resource type: | Thesis |
DOI: | 10.22024/UniKent/01.02.105291 |
KDR/KAR URL: | https://kar.kent.ac.uk/105291/ |
External URL: | https://doi.org/10.22024/UniKent/01.02.105291 |
Abstract
The ability to use bio-inspired building blocks in the assembly of novel supramolecular frameworks is at the forefront of an exciting research field. Herein, we present the first polyproline helix to self-assemble into a reversibly porous, crystalline, supramolecular peptide framework (SPF). This framework is assembled from a short oligoproline, adopting the polyproline II conformation, driven by hydrogen-bonding and dispersion interactions. Thermal activation, guest-induced dynamic porosity and enantioselective guest inclusion have been demonstrated for this novel system. The principles of the self-assembly associated with this SPF will be used as a blueprint allowing for the further development of helical peptide linkers in the rational design of SPFs and metal-peptide frameworks.
Item Type: | Article |
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DOI/Identification number: | 10.1002/chem.202202368 |
Additional information: | For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. |
Uncontrolled keywords: | General Chemistry, Catalysis, Organic Chemistry |
Subjects: | Q Science > QD Chemistry |
Divisions: | Divisions > Division of Natural Sciences > Chemistry and Forensics |
Funders: |
Engineering and Physical Sciences Research Council (https://ror.org/0439y7842)
Royal Society of Chemistry (https://ror.org/025sbr097) |
Depositing User: | Aniello Palma |
Date Deposited: | 02 Dec 2022 14:38 UTC |
Last Modified: | 11 Dec 2024 09:27 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/98647 (The current URI for this page, for reference purposes) |
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