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Ruthenium(II)-Catalyzed Double Annulation of Quinones: Step-Economical Access to Valuable Bioactive Compounds

da Silva Júnior, Eufrânio N., de Carvalho, Renato L., Almeida, Renata G., Rosa, Luisa G., Fantuzzi, Felipe, Rogge, Torben, Costa, Pedro M. S., Pessoa, Claudia, Jacob, Claus, Ackermann, Lutz and others. (2020) Ruthenium(II)-Catalyzed Double Annulation of Quinones: Step-Economical Access to Valuable Bioactive Compounds. Chemistry - A European Journal, 26 (48). pp. 10981-10986. ISSN 0947-6539. (doi:10.1002/chem.202001434) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:98544)

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Official URL:
https://doi.org/10.1002/chem.202001434

Abstract

Double ruthenium(II)-catalyzed alkyne annulations of quinones were accomplished. Thus, a strategy is reported that provides step-economical access to valuable quinones with a wide range of applications. C−H/N−H activations for alkyne annulations of naphthoquinones provided challenging polycyclic quinoidal compounds by forming four new bonds in one step. The singular power of the thus-obtained compounds was reflected by their antileukemic activity.

Item Type: Article
DOI/Identification number: 10.1002/chem.202001434
Divisions: Divisions > Division of Natural Sciences > Chemistry and Forensics
Funders: National Council for Scientific and Technological Development (https://ror.org/03swz6y49)
Alexander von Humboldt Foundation (https://ror.org/012kf4317)
Deutsche Forschungsgemeinschaft (https://ror.org/018mejw64)
German Academic Exchange Service (https://ror.org/039djdh30)
Coordenação de Aperfeicoamento de Pessoal de Nível Superior (https://ror.org/00x0ma614)
Depositing User: Felipe Fantuzzi
Date Deposited: 30 Nov 2022 19:06 UTC
Last Modified: 01 Dec 2022 17:22 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/98544 (The current URI for this page, for reference purposes)

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