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Melting Point Depression of Poly(ethylene oxide)-Poly(propylene oxide)-Poly(ethylene oxide) Triblock Polymers in Supercritical Carbon Dioxide in the Presence of Menthol as a Solid Co-Plasticiser

Trivedi, Vivek, Ajiboye, Adejumoke Lara, Coleman, Nichola, Bhomia, Ruchir, Bascougnano, Marion (2022) Melting Point Depression of Poly(ethylene oxide)-Poly(propylene oxide)-Poly(ethylene oxide) Triblock Polymers in Supercritical Carbon Dioxide in the Presence of Menthol as a Solid Co-Plasticiser. Polymers, 14 (14). Article Number 2825. ISSN 2073-4360. (doi:10.3390/polym14142825) (KAR id:98140)

Abstract

The melting behaviour of the triblock polymers, Pluronic F38, F68, F77, F108, and F127, was investigated in pressurised CO2 and in the presence of menthol. The melting points of the polymers combined with 0, 10, 25, and 50 wt% of menthol were studied at atmospheric pressure and compared with those at 10 and 20 MPa in supercritical carbon dioxide (scCO2). The highest melting point depressions of 16.8 ± 0.5 °C and 29.0 ± 0.3 °C were observed at 10 and 20 MPa, respectively. The melting point of triblock polymers in pressurised CO2 was found to be dependent on molecular weight, poly(propylene oxide) (PPO) content, and menthol percentage. The melting point of most of the polymers studied in this work can be reduced to room temperature, which can be pivotal to the formulation development of thermolabile substances using these polymers.

Item Type: Article
DOI/Identification number: 10.3390/polym14142825
Uncontrolled keywords: melting point depression; triblock polymers; supercritical carbon dioxide; solid co-plasticiser
Subjects: Q Science > QD Chemistry > QD478 Solid State Chemistry
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Funders: University of Greenwich (https://ror.org/00bmj0a71)
Depositing User: Vivek Trivedi
Date Deposited: 18 Nov 2022 14:02 UTC
Last Modified: 05 Nov 2024 13:03 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/98140 (The current URI for this page, for reference purposes)

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