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Efficacy and safety of very early mobilization after thrombolysis in acute ischemic stroke: a randomized clinical trial.

Anjos, Jorge Motta, Neto, Mansueto Gomes, de Araújo Tapparelli, Yuri, Tse, Gary, Biondi-Zoccai, Giuseppe, de Souza Lima Bitar, Yasmin, Roever, Leonardo, Duraes, Andre Rodrigues (2022) Efficacy and safety of very early mobilization after thrombolysis in acute ischemic stroke: a randomized clinical trial. Journal of neurology, . ISSN 1432-1459. (doi:10.1007/s00415-022-11411-5) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:98030)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL:
https://doi.org/10.1007/s00415-022-11411-5

Abstract

<h4>Background</h4>Stroke has a deleterious impact on human health due to its high incidence, degree of disabling sequelae and mortality, constituting one of the main causes of death and disability worldwide.<h4>Objectives</h4>This study aimed to assess the efficacy and safety of very early mobilization (VEMG) after thrombolysis in functional recovery in patients with acute ischemic stroke.<h4>Methods</h4>The present study was an open, prospective, randomized study, with no blinded outcome, carried out in the stroke unit of a tertiary referral hospital located in Salvador-Bahia, Brazil. The primary outcome was the level of functional independence. Secondary outcomes were functional mobility, balance, complications within 7 days of hospitalization and 90 days after hospital discharge, and length of stay.<h4>Outcomes</h4>A total of 104 patients with ischemic stroke who received thrombolytic treatment between August 2020 and July 2021 were prospectively recruited to the study. Of these, 51 patients received VEMG within 24 h of the ictus and another 53 patients receiving usual care (UCG) with mobilization 24 h after the ictus. When compared to the usual care, the VEMG group was not associated with a significant reduction in the risk of the primary outcome (relative risk [95% confidence intervals]: 0.74 [0.339-1.607]) or any of the secondary outcomes.<h4>Conclusion</h4>In this study, the strategy of early mobilization after thrombolysis in ischemic stroke was safe, but without evidence of short-term benefit. Brazilian Registry of Clinical Trials under the registry (registry number: RBR-8bgcs3).

Item Type: Article
DOI/Identification number: 10.1007/s00415-022-11411-5
Additional information: ** From Europe PMC via Jisc Publications Router ** History: ppub 01-10-2022; epub 11-10-2022.
Uncontrolled keywords: Stroke, Stroke Rehabilitation, Early Mobilization, Motor Recovery
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: University of Kent (https://ror.org/00xkeyj56)
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 16 Nov 2022 16:10 UTC
Last Modified: 17 Nov 2022 12:15 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/98030 (The current URI for this page, for reference purposes)

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