Yang, K, Boles, Jessica Emily, White, Lisa Jane, Hilton, Kira L.F., Lai, H. Y., Long, Y., Hiscock, Jennifer R. (2022) A water-soluble membrane transporter for biologically relevant cations. RSC Advances, 12 (43). pp. 27877-27880. ISSN 2046-2069. (doi:10.1039/D2RA05314D) (KAR id:96989)
PDF
Publisher pdf
Language: English
This work is licensed under a Creative Commons Attribution 4.0 International License.
|
|
Download (401kB)
Preview
|
Preview |
This file may not be suitable for users of assistive technology.
Request an accessible format
|
|
PDF
Author's Accepted Manuscript
Language: English |
|
Download (360kB)
Preview
|
Preview |
This file may not be suitable for users of assistive technology.
Request an accessible format
|
|
PDF
Supplemental Material
Language: English |
|
Download (1MB)
Preview
|
Preview |
This file may not be suitable for users of assistive technology.
Request an accessible format
|
|
Official URL: https://doi.org/10.1039/D2RA05314D |
Abstract
Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic insight through planar bilayer patch clamp experiments.
Item Type: | Article |
---|---|
DOI/Identification number: | 10.1039/D2RA05314D |
Subjects: |
Q Science Q Science > QD Chemistry |
Divisions: | Divisions > Division of Natural Sciences > Chemistry and Forensics |
Funders: |
UK Research and Innovation (https://ror.org/001aqnf71)
University of Kent (https://ror.org/00xkeyj56) |
Depositing User: | Jennifer Hiscock |
Date Deposited: | 19 Sep 2022 18:10 UTC |
Last Modified: | 10 Oct 2022 14:28 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/96989 (The current URI for this page, for reference purposes) |
Hiscock, Jennifer R.: | ![]() |
- Link to SensusAccess
- Export to:
- RefWorks
- EPrints3 XML
- BibTeX
- CSV
- Depositors only (login required):