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A water-soluble membrane transporter for biologically relevant cations

Yang, K, Boles, Jessica Emily, White, Lisa Jane, Hilton, Kira L.F., Lai, H. Y., Long, Y., Hiscock, Jennifer R. (2022) A water-soluble membrane transporter for biologically relevant cations. RSC Advances, 12 (43). pp. 27877-27880. ISSN 2046-2069. (doi:10.1039/D2RA05314D) (KAR id:96989)

Abstract

Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic insight through planar bilayer patch clamp experiments.

Item Type: Article
DOI/Identification number: 10.1039/D2RA05314D
Subjects: Q Science
Q Science > QD Chemistry
Divisions: Divisions > Division of Natural Sciences > Chemistry and Forensics
Funders: UK Research and Innovation (https://ror.org/001aqnf71)
University of Kent (https://ror.org/00xkeyj56)
Depositing User: Jennifer Hiscock
Date Deposited: 19 Sep 2022 18:10 UTC
Last Modified: 11 Jan 2024 06:35 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/96989 (The current URI for this page, for reference purposes)

University of Kent Author Information

Boles, Jessica Emily.

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White, Lisa Jane.

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Hilton, Kira L.F..

Creator's ORCID:
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Hiscock, Jennifer R..

Creator's ORCID: https://orcid.org/0000-0002-1406-8802
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