Yang, K, Boles, Jessica Emily, White, Lisa Jane, Hilton, Kira L.F., Lai, H. Y., Long, Y., Hiscock, Jennifer R. (2022) A water-soluble membrane transporter for biologically relevant cations. RSC Advances, 12 (43). pp. 27877-27880. ISSN 2046-2069. (doi:10.1039/D2RA05314D) (KAR id:96989)
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| Official URL: https://doi.org/10.1039/D2RA05314D |
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Abstract
Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic insight through planar bilayer patch clamp experiments.
| Item Type: | Article |
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| DOI/Identification number: | 10.1039/D2RA05314D |
| Subjects: |
Q Science Q Science > QD Chemistry |
| Institutional Unit: | Schools > School of Natural Sciences > Chemistry and Forensic Science |
| Former Institutional Unit: |
Divisions > Division of Natural Sciences > Chemistry and Forensics
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| Funders: |
UK Research and Innovation (https://ror.org/001aqnf71)
University of Kent (https://ror.org/00xkeyj56) |
| Depositing User: | Jennifer Hiscock |
| Date Deposited: | 19 Sep 2022 18:10 UTC |
| Last Modified: | 22 Jul 2025 09:11 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/96989 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Boles, Jessica Emily.
| Creator's ORCID: | |
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| CReDIT Contributor Roles: |
White, Lisa Jane.
| Creator's ORCID: |
 https://orcid.org/0000-0001-9492-6143
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| CReDIT Contributor Roles: |
Hilton, Kira L.F..
| Creator's ORCID: | |
|---|---|
| CReDIT Contributor Roles: |
Hiscock, Jennifer R..
| Creator's ORCID: |
https://orcid.org/0000-0002-1406-8802
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|---|---|
| CReDIT Contributor Roles: |
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