A water-soluble membrane transporter for biologically relevant cations

Yang, K, Boles, Jessica Emily, White, Lisa Jane, Hilton, Kira L.F., Lai, H. Y., Long, Y., Hiscock, Jennifer R. (2022) A water-soluble membrane transporter for biologically relevant cations. RSC Advances, 12 (43). pp. 27877-27880. ISSN 2046-2069. (doi:10.1039/D2RA05314D) (KAR id:96989)

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Official URL: https://doi.org/10.1039/D2RA05314D

Abstract

Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic insight through planar bilayer patch clamp experiments.

Item Type:	Article
DOI/Identification number:	10.1039/D2RA05314D
Subjects:	Q Science Q Science > QD Chemistry
Divisions:	Divisions > Division of Natural Sciences > Chemistry and Forensics
Funders:	UK Research and Innovation (https://ror.org/001aqnf71) University of Kent (https://ror.org/00xkeyj56)
Depositing User:	Jennifer Hiscock
Date Deposited:	19 Sep 2022 18:10 UTC
Last Modified:	05 Nov 2024 13:01 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/96989 (The current URI for this page, for reference purposes)

University of Kent Author Information

Boles, Jessica Emily.

Creator's ORCID:
CReDIT Contributor Roles:

White, Lisa Jane.

Creator's ORCID:	https://orcid.org/0000-0001-9492-6143
CReDIT Contributor Roles:

Hilton, Kira L.F..

Creator's ORCID:
CReDIT Contributor Roles:

Hiscock, Jennifer R..

Creator's ORCID:	https://orcid.org/0000-0002-1406-8802
CReDIT Contributor Roles:

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