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Cognitive correlates of abnormal myelination in psychosis

Vanes, Lucy D., Mouchlianitis, Elias, Barry, Erica, Patel, Krisna, Wong, Katie, Shergill, Sukhwinder S. (2019) Cognitive correlates of abnormal myelination in psychosis. Scientific Reports, 9 (1). ISSN 2045-2322. (doi:10.1038/s41598-019-41679-z) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:96391)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL:
https://doi.org/10.1038/s41598-019-41679-z

Abstract

Psychotic illness has consistently been associated with deficits in cognitive function and reduced white matter integrity in the brain. However, the link between white matter disruptions and deficits in cognitive domains remains poorly understood. We assessed cognitive performance and white matter myelin water fraction (MWF) using multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT) in recent-onset psychosis patients and age-matched healthy controls (HC). Psychosis patients showed deficits in working memory, phonological and semantic fluency, general intelligence quotient and reduced MWF in the left temporal white matter compared to HC. MWF in the left inferior fronto-occipital fasciculus and inferior longitudinal fasciculus was positively associated with intelligence quotient and verbal fluency in patients, and fully mediated group differences in performance in both phonological and semantic verbal fluency. There was no association between working memory and MWF in the left temporal white matter. Negative symptoms demonstrated a negative association with MWF within the left inferior and superior longitudinal fasciculi. These findings indicate that psychosis-related deficits in distinct cognitive domains, such as verbal fluency and working memory, are not underpinned by a single common dysfunction in white matter connectivity.

Item Type: Article
DOI/Identification number: 10.1038/s41598-019-41679-z
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: European Research Council (https://ror.org/0472cxd90)
Depositing User: Rachael Heller
Date Deposited: 03 Oct 2022 09:28 UTC
Last Modified: 04 Oct 2022 13:56 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/96391 (The current URI for this page, for reference purposes)

University of Kent Author Information

Shergill, Sukhwinder S..

Creator's ORCID: https://orcid.org/0000-0003-4928-9100
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