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Clozapine and cardiotoxicity - A guide for psychiatrists written by cardiologists

Patel, Rishi K., Moore, Alice M., Piper, Susan, Sweeney, Mark, Whiskey, Eromona, Cole, Graham, Shergill, Sukhi S., Plymen, Carla M. (2019) Clozapine and cardiotoxicity - A guide for psychiatrists written by cardiologists. Psychiatry Research, 282 . ISSN 0165-1781. (doi:10.1016/j.psychres.2019.112491) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:96390)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL:
https://doi.org/10.1016/j.psychres.2019.112491

Abstract

This review discusses the rare but potentially life-threatening cardiovascular side-effects of myocarditis and dilated cardiomyopathy associated with the use of Clozapine. The clinical presentation of these conditions is non-specific, making it difficult to both risk-stratify and identify patients who develop these consequences. This review aims to examine the proposed aetiologies, diagnostic approaches and subsequent management strategies of cardiotoxicity associated with clozapine use; offering guidance to psychiatrists and general physicians. Current evidence highlights the importance of accurate diagnosis to prevent premature and unnecessary cessation of clozapine. Guidance on monitoring and reintroduction of the drug is emerging and current practice recommends a combination of regular monitoring of biomarkers and imaging to make a diagnosis of cardiotoxicity although further work is needed to establish evidence-based guidelines.

Item Type: Article
DOI/Identification number: 10.1016/j.psychres.2019.112491
Uncontrolled keywords: Cardiomyopathy, Myocarditis, Pharmacotherapy, Psychosis, Schizophrenia
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Depositing User: Rachael Heller
Date Deposited: 29 Sep 2022 10:08 UTC
Last Modified: 05 Nov 2024 13:01 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/96390 (The current URI for this page, for reference purposes)

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