Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces

Papanastasiou, Evangelos, Mouchlianitis, Elias, Joyce, Dan W., McGuire, Philip, Boussebaa, Celia, Banaschewski, Tobias, Bokde, Arun L.W., Büchel, Christian, Quinlan, Erin, Desrivières, Sylvane, and others. (2020) Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces. Scientific Reports, 10 (1). ISSN 2045-2322. (doi:10.1038/s41598-020-62026-7) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:96382)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL: https://doi.org/10.1038/s41598-020-62026-7

Abstract

Contemporary theories propose that dysregulation of emotional perception is involved in the aetiology of psychosis. 298 healthy adolescents were assessed at age 14- and 19-years using fMRI while performing a facial emotion task. Psychotic-like experiences (PLEs) were assessed with the CAPE-42 questionnaire at age 19. The high PLEs group at age 19 years exhibited an enhanced response in right insular cortex and decreased response in right prefrontal, right parahippocampal and left striatal regions; also, a gradient of decreasing response to emotional faces with age, from 14 to 19 years, in the right parahippocampal region and left insular cortical area. The right insula demonstrated an increasing response to emotional faces with increasing age in the low PLEs group, and a decreasing response over time in the high PLEs group. The change in parahippocampal/amygdala and insula responses during the perception of emotional faces in adolescents with high PLEs between the ages of 14 and 19 suggests a potential 'aberrant' neurodevelopmental trajectory for critical limbic areas. Our findings emphasize the role of the frontal and limbic areas in the aetiology of psychotic symptoms, in subjects without the illness phenotype and the confounds introduced by antipsychotic medication.

Item Type:	Article
DOI/Identification number:	10.1038/s41598-020-62026-7
Additional information:	This work received support from the following sources: the European Union-funded FP6 Integrated Project IMAGEN (Reinforcement-related behaviour in normal brain function and psychopathology) (LSHM-CT- 2007-037286), the Horizon 2020 funded European Research Council Advanced Grant ‘STRATIFY’ (Brain network based stratification of reinforcement-related disorders) (695313), ERANID (Understanding the Interplay between Cultural, Biological and Subjective Factors in Drug Use Pathways) (PR-ST-0416-10004), BRIDGET (JPND: BRain Imaging, cognition Dementia, and next generation GEnomics) (MR/N027558/1), the FP7 projects IMAGEMEND(602450; IMAging GEnetics for MENtal Disorders), and MATRICS (603016), the Innovative Medicine Initiative Project EU-AIMS (115300-2), the Medical Research Council Grant ‘c-VEDA’ (Consortium on Vulnerability to Externalizing Disorders and Addictions) (MR/N000390/1), the Swedish Research Council FORMAS, the Medical Research Council, the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, and King’s College London, the Bundesministeriumfür Bildung und Forschung (BMBF grants 01GS08152; 01EV0711; eMED SysAlc01ZX1311A; Forschungsnetz AERIAL), the Deutsche Forschungsgemeinschaft (DFG grants SM 80/7-1, SM 80/7-2, SFB 940/1, NE 1383/14-1). Further support was provided by grants from: ANR (project AF12-NEUR0008-01 - WM2NA, and ANR-12-SAMA-0004), the Fondation de France, the Fondation pour la Recherche Médicale, the Mission Interministérielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA), the Fondation pour la Recherche Médicale (DPA20140629802), the Fondation de l’Avenir, Paris Sud University IDEX 2012; the National Institutes of Health, Science Foundation Ireland (16/ERCD/3797), U.S.A. (Axon, Testosterone and Mental Health during Adolescence; RO1 MH085772-01A1), and by NIH Consortium grant U54 EB020403, supported by a cross-NIH alliance that funds Big Data to Knowledge Centres of Excellence. This paper represents independent research part-funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. All funders and sponsors had no role in the design and conduct of the study: collection, management analysis, and interpretation of the data; preparation review and approval of the manuscript; and decision to submit the manuscript for publication.
Subjects:	R Medicine
Divisions:	Divisions > Division of Natural Sciences > Kent and Medway Medical School
Depositing User:	Rachael Heller
Date Deposited:	29 Sep 2022 08:48 UTC
Last Modified:	05 Nov 2024 13:01 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/96382 (The current URI for this page, for reference purposes)

University of Kent Author Information

Shergill, Sukhwinder S..

Creator's ORCID:	https://orcid.org/0000-0003-4928-9100
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