Skip to main content
Kent Academic Repository

Predictors of fatal arrhythmic events in patients with non-compaction cardiomyopathy: a systematic review.

Bazoukis, George, Tyrovolas, Konstantinos, Letsas, Konstantinos P, Vlachos, Konstantinos, Radford, Danny, Chung, Cheuk To, Liu, Tong, Efremidis, Michael, Tse, Gary, Baranchuk, Adrian and others. (2022) Predictors of fatal arrhythmic events in patients with non-compaction cardiomyopathy: a systematic review. Heart failure reviews, 27 . pp. 2067-2076. ISSN 1573-7322. (doi:10.1007/s10741-022-10257-3) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:95819)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL:
https://doi.org/10.1007/s10741-022-10257-3

Abstract

Left ventricular non-compaction cardiomyopathy (LVNC) is a congenital heart disease with autosomal dominant inheritance. This review aims to summarize the existing data about the predictors of fatal arrhythmias in patients with LVNC. Medline and Cochrane library databases were searched from inception to November 2021 for articles on LVNC. The reference lists of the relevant research studies as well as the relevant review studies and meta-analyses were also searched. Clinical symptoms and electrocardiogram findings such as left bundle branch block are significantly associated with ventricular arrhythmias. Other non-invasive tools such as Holter monitoring, echocardiography, and cardiac magnetic resonance (CMR) can provide additional value for risk stratification. CMR-derived left and right ventricular ejection fraction, left ventricular end-diastolic diameter, late gadolinium enhancement, and non-compacted to compacted myocardium ratio are predictive of ventricular arrhythmias. An electrophysiological study can provide additional prognostic data in patients with LVNC who are at moderate risk of ventricular arrhythmias. Risk stratification of LVNC patients with no prior history of a fatal arrhythmic event remains challenging. Symptoms assessment, electrocardiogram, Holter monitoring, and cardiac imaging should be performed on every patient, while an electrophysiological study should be performed for moderate-risk patients. Large cohort studies are needed for the construction of score models for arrhythmic risk stratification purposes.

Item Type: Article
DOI/Identification number: 10.1007/s10741-022-10257-3
Additional information: ** From PubMed via Jisc Publications Router ** History: accepted 20-06-2022.
Uncontrolled keywords: Sudden cardiac death, Cardiomyopathies, Risk stratification, Ventricular arrhythmias, Left ventricular non-compaction
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: University of Kent (https://ror.org/00xkeyj56)
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 22 Nov 2022 11:35 UTC
Last Modified: 23 Nov 2022 10:58 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/95819 (The current URI for this page, for reference purposes)

University of Kent Author Information

Radford, Danny.

Creator's ORCID:
CReDIT Contributor Roles:

Tse, Gary.

Creator's ORCID: https://orcid.org/0000-0001-5510-1253
CReDIT Contributor Roles:
  • Depositors only (login required):

Total unique views for this document in KAR since July 2020. For more details click on the image.