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An in vitro evaluation of fenugreek mucilage as a potential excipient for oral controlled-release matrix tablet

Nokhodchi, Ali, Nazemieeyeh, Hossein, Khpdaparast, Afagh, Sorkh-shahan, Tarifeh, Ford, J.L. (2008) An in vitro evaluation of fenugreek mucilage as a potential excipient for oral controlled-release matrix tablet. Drug Development and Industrial Pharmacy, 34 (3). pp. 323-329. ISSN 0363-9045. (doi:10.1080/03639040701662594) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:9324)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1080/03639040701662594

Abstract

A polysaccharide mucilage derived from the seeds of fenugreek,Trigonella oenum-graceum L (family Fabaceae) was investigated for use in matrix formulations containing propranolol hydrochloride. Methocel® hypomellose K4M was used as a standard controlled release polymer for comparison purposes. In this study the effect of lactose on the release behaviour of propranolol hydrochloride from matrices formulated to contain the fenugreek mucilage

also was investigated. An increase in concentration of the mucilage in matrices resulted in a reduction in the release rate of propranolol hydrochloride comparable to that observed with hypomellose matrices. The rate of release of propranolol hydrochloride from fenugreek mucilage matrices was mainly controlled by the drug:mucilage ratio. However, the mechanism of release

from matrices containing drug:mucilage ratios of 1:1, 1:1.25, 1:1.5, and 1:2 remained the same. The kinetics of release, utilising the release exponent n, showed that the values of n were between 0.46–0.57 indicating that the release from fenugreek mucilage matrices was predominantly by diffusion. The presence of lactose in matrices containing mucilage increased the release rate of propranolol hydrochloride. This is due to a reduction in tortuoisity and increased pore size of channels caused by lactose through which propranolol diffuses and therefore diffusion of water into the tablet is facilitated.

Item Type: Article
DOI/Identification number: 10.1080/03639040701662594
Uncontrolled keywords: fenugreek mucilage; propranolol hydrochloride; release rate; mechanism of release
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Ali Nokhodchi
Date Deposited: 17 Mar 2009 12:38 UTC
Last Modified: 05 Nov 2024 09:42 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/9324 (The current URI for this page, for reference purposes)

University of Kent Author Information

Nokhodchi, Ali.

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