Truncated azinomycin analogues intercalated into DNA

Casely-Hayford, Maxwell A. and Pors, Klaus and Patterson, Laurence H. and Gernera, Clive and Neidle, Stephen and Searcey, Mark (2005) Truncated azinomycin analogues intercalated into DNA. Bioorganic & Medicinal Chemistry Letters, 15 (3). 653-656. ISSN 0960-894X. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based upon 3 has been completed. It involved coupling of a piperidine mustard to the acid chloride of the azinomycin chromophore. Both the designed azinomycin analogue 4 and the natural product 3 bind to DNA and cause unwinding, supporting an intercalative mode of binding.

Item Type: Article
Projects: [50] Azinomycins
Uncontrolled keywords: Azinomycin; Intercalation; DNA unwinding; Synthesis; Analogues
Subjects: Q Science
Q Science > QD Chemistry
Divisions: Faculties > Science Technology and Medical Studies > Medway School of Pharmacy
Depositing User: Maxwell Casely-Hayford
Date Deposited: 18 Nov 2008 13:00
Last Modified: 22 Apr 2014 14:35
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