Skip to main content

Truncated azinomycin analogues intercalated into DNA

Casely-Hayford, Maxwell A., Pors, Klaus, Patterson, Laurence H., Gernera, Clive, Neidle, Stephen, Searcey, Mark (2005) Truncated azinomycin analogues intercalated into DNA. Bioorganic & Medicinal Chemistry Letters, 15 (3). pp. 653-656. ISSN 0960-894X. (doi:10.1016/j.bmcl.2004.11.037) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1016/j.bmcl.2004.11.037

Abstract

The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based upon 3 has been completed. It involved coupling of a piperidine mustard to the acid chloride of the azinomycin chromophore. Both the designed azinomycin analogue 4 and the natural product 3 bind to DNA and cause unwinding, supporting an intercalative mode of binding.

Item Type: Article
DOI/Identification number: 10.1016/j.bmcl.2004.11.037
Projects: [50] Azinomycins
Uncontrolled keywords: Azinomycin; Intercalation; DNA unwinding; Synthesis; Analogues
Subjects: Q Science
Q Science > QD Chemistry
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Maxwell Casely-Hayford
Date Deposited: 18 Nov 2008 13:00 UTC
Last Modified: 28 May 2019 13:45 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/9224 (The current URI for this page, for reference purposes)
  • Depositors only (login required):