Truncated azinomycin analogues intercalated into DNA

Casely-Hayford, Maxwell A., Pors, Klaus, Patterson, Laurence H., Gernera, Clive, Neidle, Stephen, Searcey, Mark (2005) Truncated azinomycin analogues intercalated into DNA. Bioorganic & Medicinal Chemistry Letters, 15 (3). pp. 653-656. ISSN 0960-894X. (doi:10.1016/j.bmcl.2004.11.037) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:9224)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: http://dx.doi.org/10.1016/j.bmcl.2004.11.037

Abstract

The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based upon 3 has been completed. It involved coupling of a piperidine mustard to the acid chloride of the azinomycin chromophore. Both the designed azinomycin analogue 4 and the natural product 3 bind to DNA and cause unwinding, supporting an intercalative mode of binding.

Item Type:	Article
DOI/Identification number:	10.1016/j.bmcl.2004.11.037
Projects:	Azinomycins
Uncontrolled keywords:	Azinomycin; Intercalation; DNA unwinding; Synthesis; Analogues
Subjects:	Q Science Q Science > QD Chemistry
Institutional Unit:	Schools > Medway School of Pharmacy
Former Institutional Unit:	Divisions > Division of Natural Sciences > Medway School of Pharmacy
Funders:	Engineering and Physical Sciences Research Council (https://ror.org/0439y7842) Coleg Prifysgol Llundain (https://ror.org/02jx3x895)
Depositing User:	Maxwell Casely-Hayford
Date Deposited:	18 Nov 2008 13:00 UTC
Last Modified:	20 May 2025 09:53 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/9224 (The current URI for this page, for reference purposes)

University of Kent Author Information

Casely-Hayford, Maxwell A..

Creator's ORCID:	https://orcid.org/0000-0003-4054-4371
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