Casely-Hayford, Maxwell A., Pors, Klaus, Patterson, Laurence H., Gernera, Clive, Neidle, Stephen, Searcey, Mark (2005) Truncated azinomycin analogues intercalated into DNA. Bioorganic & Medicinal Chemistry Letters, 15 (3). pp. 653-656. ISSN 0960-894X. (doi:10.1016/j.bmcl.2004.11.037) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:9224)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: http://dx.doi.org/10.1016/j.bmcl.2004.11.037 |
Abstract
The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based upon 3 has been completed. It involved coupling of a piperidine mustard to the acid chloride of the azinomycin chromophore. Both the designed azinomycin analogue 4 and the natural product 3 bind to DNA and cause unwinding, supporting an intercalative mode of binding.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1016/j.bmcl.2004.11.037 |
| Projects: | Azinomycins |
| Uncontrolled keywords: | Azinomycin; Intercalation; DNA unwinding; Synthesis; Analogues |
| Subjects: |
Q Science Q Science > QD Chemistry |
| Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
| Funders: |
Engineering and Physical Sciences Research Council (https://ror.org/0439y7842)
University College London (https://ror.org/02jx3x895) |
| Depositing User: | Maxwell Casely-Hayford |
| Date Deposited: | 18 Nov 2008 13:00 UTC |
| Last Modified: | 05 Nov 2024 09:42 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/9224 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Casely-Hayford, Maxwell A..
| Creator's ORCID: |
 https://orcid.org/0000-0003-4054-4371
|
|---|---|
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