Bottigli, U., Brunetti, A., Carpinelli, M., Diaz, N, Fiori, P.L., Golosio, B., Masala, G.L., Oliva, P., Randaccio, P., Santona, S, and others. (2008) Effect of cryo-preservation on the response of different biological systems to γ-ray exposure: a feasibility study. Nuovo Cimento della Societa Italiana di Fisica. C, Geophysics and Space Physics, 31 (1). pp. 11-20. ISSN 1124-1896. (doi:10.1393/ncc/i2008-10276-6) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:91805)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: https://www.sif.it/riviste/sif/ncc/econtents/2008/... |
Abstract
Cryo preservation of cells, tissues or organisms (i.e. the storage at liquid-nitrogen or nitrogen vapour temperature) offers the most secure form of preservation, allowing cells to be maintained unaltered for a long time and preventing them from ageing. On the other hand, the multi-year exposure of cryo-preserved cells (like: stem and germ cells) to the environmental γ-ray background might induce a radiation-damage accumulation, due to the inhibition of cellular repair mechanisms, and contribute to cancer or non-cancer pathology risk assessment when such cells should be transplanted in individuals. To investigate the effect of the cryo preservation on the cell response to radiation exposures, the response of different biological systems (bacteria and mammalian cells) to γ-rays has been evaluated after irradiation in cryo-preserved and culture conditions, as a function of dose and dose rate, in terms of a variety of cellular and molecular end-points.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1393/ncc/i2008-10276-6 |
| Uncontrolled keywords: | Cryobiology; dosimetry; gamma radiation, ionizing radiation, electromagnetic radiation; radiation |
| Subjects: | Q Science > QA Mathematics (inc Computing science) > QA 75 Electronic computers. Computer science |
| Divisions: | Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Computing |
| Depositing User: | Amy Boaler |
| Date Deposited: | 30 Nov 2021 15:31 UTC |
| Last Modified: | 05 Nov 2024 12:57 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/91805 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Masala, G.L..
| Creator's ORCID: |
 https://orcid.org/0000-0001-6734-9424
|
|---|---|
| CReDIT Contributor Roles: |
- Export to:
- RefWorks
- EPrints3 XML
- BibTeX
- CSV
- Depositors only (login required):
Altmetric
Altmetric
