Sheth, Chirag C., Hall, Rebecca A., Lewis, Leanne, Brown, Alistair J. P., Odds, Frank C., Erwig, Lars P., Gow, Neil A. R. (2011) Glycosylation status of theC. albicanscell wall affects the efficiency of neutrophil phagocytosis and killing but not cytokine signaling. Medical Mycology, 49 (5). pp. 513-524. ISSN 1369-3786. (doi:10.3109/13693786.2010.551425) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:91783)
The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
Official URL: https://doi.org/10.3109/13693786.2010.551425 |
Abstract
The cell wall of the opportunistic human fungal pathogen, Candida albicans is a complex, layered network of rigid structural polysaccharides composed of β-glucans and chitin that is covered with a fibrillar matrix of highly glycosylated mannoproteins. Polymorphonuclear cells (PMNs, neutrophils) are the most prevalent circulating phagocytic leukocyte in peripheral blood and they are pivotal in the clearance of invading fungal cells from tissues. The importance of cell-wall mannans for the recognition and uptake of C. albicans by human PMNs was therefore investigated. N- and O-glycosylation-deficient mutants were attenuated in binding and phagocytosis by PMNs and this was associated with reduced killing of C. albicans yeast cells. No differences were found in the production of the respiratory burst enzyme myeloperoxidase (MPO) and the neutrophil chemokine IL-8 in PMNs exposed to control and glycosylation-deficient C. albicans strains. Thus, the significant decrease in killing of glycan-deficient C. albicans strains by PMNs is a consequence of a marked reduction in phagocytosis rather than changes in the release of inflammatory mediators by PMNs.
Item Type: | Article |
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DOI/Identification number: | 10.3109/13693786.2010.551425 |
Uncontrolled keywords: | C. albicans, glycosylation, innate immunity, PMN |
Subjects: | Q Science > QR Microbiology |
Divisions: | Divisions > Division of Natural Sciences > Biosciences |
Depositing User: | Becky Hall |
Date Deposited: | 30 Nov 2021 11:22 UTC |
Last Modified: | 05 Nov 2024 12:57 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/91783 (The current URI for this page, for reference purposes) |
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