Antoccia, A., Argazzi, E., Balata, M., Bedogni, R., Berardinelli, F., Bisogni, G., Bono, M., Bottigli, U., Brunetti, A., Buttafava, A., and others. (2011) Low-dose effects of ionizing radiations in in vitro and in vivo biological systems: A multi-scale approach study. Nuovo Cimento della Societa Italiana di Fisica C, 34 (1). pp. 49-63. ISSN 2037-4909. (doi:10.1393/ncc/i2011-10806-1) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:91427)
The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
Official URL: https://doi:10.1393/ncc/i2011-10806-1 |
Abstract
Long-term biological effects of low-dose radiation are little known nowadays and its carcinogenic risk is estimated on the assumption that the risk remains linearly proportional to the radiation dose down to low-dose levels. However in the last 20 years this hypothesis has gradually begun to seem in contrast with a huge collection of experimental evidences, which has shown the presence of a plethora of non-linear phenomena (including hypersensitivity and induced radioresistance, adaptive response, and non-targeted phenomena like bystander effect and genomic instability) occurring after low-dose irradiation. These phenomena might imply a non-linear behaviour of cancer risk curves in the low-dose region and question the validity of the Linear No-Threshold (LNT) model currently used for cancer risk assessment through extrapolation from existing high-dose data. Moreover only few information is available regarding the effects induced on cryopreserved cells by multi-year background radiation exposure, which might induce a radiation-damage accumulation, due to the inhibition of cellular repair mechanisms. In this framework, the multi-year EXCALIBUR (EXposure effeCts At Low doses of Ionizing radiation in Biological CultURes) experiment, funded by INFN-CNS5, has undertaken a multiscale approach investigation on the biological effects induced in in vitro and in vivo biological systems, in culture and cryopreserved conditions, as a function of radiation quality (X/γ-rays, protons, He-4 ions of various energies) and dose, with particular emphasis on the low-dose region and non-linear phenomena, in terms of different biological endpoints.
Item Type: | Article |
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DOI/Identification number: | 10.1393/ncc/i2011-10806-1 |
Additional information: | cited By 0 |
Subjects: | Q Science > QA Mathematics (inc Computing science) > QA 75 Electronic computers. Computer science |
Divisions: | Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Computing |
Depositing User: | Amy Boaler |
Date Deposited: | 08 Nov 2021 14:33 UTC |
Last Modified: | 16 Nov 2021 10:27 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/91427 (The current URI for this page, for reference purposes) |
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