Low-dose effects of ionizing radiations in in vitro and in vivo biological systems: A multi-scale approach study

Antoccia, A., Argazzi, E., Balata, M., Bedogni, R., Berardinelli, F., Bisogni, G., Bono, M., Bottigli, U., Brunetti, A., Buttafava, A., and others. (2011) Low-dose effects of ionizing radiations in in vitro and in vivo biological systems: A multi-scale approach study. Nuovo Cimento della Societa Italiana di Fisica C, 34 (1). pp. 49-63. ISSN 2037-4909. (doi:10.1393/ncc/i2011-10806-1) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:91427)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: https://doi:10.1393/ncc/i2011-10806-1

Abstract

Long-term biological effects of low-dose radiation are little known nowadays and its carcinogenic risk is estimated on the assumption that the risk remains linearly proportional to the radiation dose down to low-dose levels. However in the last 20 years this hypothesis has gradually begun to seem in contrast with a huge collection of experimental evidences, which has shown the presence of a plethora of non-linear phenomena (including hypersensitivity and induced radioresistance, adaptive response, and non-targeted phenomena like bystander effect and genomic instability) occurring after low-dose irradiation. These phenomena might imply a non-linear behaviour of cancer risk curves in the low-dose region and question the validity of the Linear No-Threshold (LNT) model currently used for cancer risk assessment through extrapolation from existing high-dose data. Moreover only few information is available regarding the effects induced on cryopreserved cells by multi-year background radiation exposure, which might induce a radiation-damage accumulation, due to the inhibition of cellular repair mechanisms. In this framework, the multi-year EXCALIBUR (EXposure effeCts At Low doses of Ionizing radiation in Biological CultURes) experiment, funded by INFN-CNS5, has undertaken a multiscale approach investigation on the biological effects induced in in vitro and in vivo biological systems, in culture and cryopreserved conditions, as a function of radiation quality (X/γ-rays, protons, He-4 ions of various energies) and dose, with particular emphasis on the low-dose region and non-linear phenomena, in terms of different biological endpoints.

Item Type:	Article
DOI/Identification number:	10.1393/ncc/i2011-10806-1
Additional information:	cited By 0
Subjects:	Q Science > QA Mathematics (inc Computing science) > QA 75 Electronic computers. Computer science
Divisions:	Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Computing
Depositing User:	Amy Boaler
Date Deposited:	08 Nov 2021 14:33 UTC
Last Modified:	05 Nov 2024 12:57 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/91427 (The current URI for this page, for reference purposes)

University of Kent Author Information

Masala, Giovanni Luca.

Creator's ORCID:	https://orcid.org/0000-0001-6734-9424
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