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Neuronal SKN-1B Modulates Nutritional Signalling Pathways and Mitochondrial Networks to Control Satiety

Tataridas-Pallas, Nikolaos (2021) Neuronal SKN-1B Modulates Nutritional Signalling Pathways and Mitochondrial Networks to Control Satiety. Doctor of Philosophy (PhD) thesis, University of Kent,. (doi:10.22024/UniKent/01.02.91366) (KAR id:91366)

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Official URL:
https://doi.org/10.22024/UniKent/01.02.91366

Abstract

Correct responses to nutrient type and availability are a crucial mater for all living organisms. In animals, food-related decisions require the communication of the sensory nervous system with internal body cues. Hunger and satiety play an important role here, controlling food intake and maintaining nutrient homeostasis. In C. elegans, chemosensory neurons sense food and relay information to the rest of the animal via hormones, neurotransmitters, and neuropeptides. These responses have a direct impact in worms’ behaviour and physiology. This study shows that SKN-1B, an ortholog of the mammalian NF-E2 related transcription factors (Nrfs), acts in the two hypothalamus-like ASI chemosensory neurons to sense food,

communicate nutritional status to the organism, and control food-related behaviours. SKN-1B modulates IIS and TGF-β pathways to suppress satiety-induced quiescence and promote exploratory behaviour. Finally, SKN-1B influences physiology by promoting a robust mitochondrial network which is required for energy homeostasis. The work presented here, suggests an exciting role for mammalian Nrf proteins in food-sensing and satiety.

Item Type: Thesis (Doctor of Philosophy (PhD))
Thesis advisor: Tullet, Jennifer
DOI/Identification number: 10.22024/UniKent/01.02.91366
Uncontrolled keywords: satiety, Neuronal SKN-1B
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Divisions > Division of Natural Sciences > Biosciences
SWORD Depositor: System Moodle
Depositing User: System Moodle
Date Deposited: 09 Nov 2021 10:18 UTC
Last Modified: 14 Nov 2022 23:13 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/91366 (The current URI for this page, for reference purposes)
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