Goult, Benjamin T., Brown, Nicholas H., Schwartz, Martin A. (2021) Talin in mechanotransduction and mechanomemory at a glance. Journal of Cell Science, 134 (20). Article Number jcs258749. ISSN 0021-9533. E-ISSN 1477-9137. (doi:10.1242/jcs.258749) (KAR id:91148)
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Official URL: https://doi.org/10.1242/jcs.258749 |
Abstract
Talins are cytoskeletal linker proteins that consist of an N-terminal head domain, a flexible neck region and a C-terminal rod domain made of 13 helical bundles. The head domain binds integrin β-subunit cytoplasmic tails, which triggers integrin conformational activation to increase affinity for extracellular matrix proteins. The rod domain links to actin filaments inside the cell to transmit mechanical loads and serves as a mechanosensitive signalling hub for the recruitment of many other proteins. The α-helical bundles function as force-dependent switches – proteins that interact with folded bundles are displaced when force induces unfolding, exposing previously cryptic binding sites for other ligands. This leads to the notion of a talin code. In this Cell Science at a Glance article and the accompanying poster, we propose that the multiple switches within the talin rod function to process and store time- and force-dependent mechanical and chemical information.
Item Type: | Article |
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DOI/Identification number: | 10.1242/jcs.258749 |
Uncontrolled keywords: | Integrin, Mechanobiology, Mechanomemory, Mechanotransduction, Memory, MeshCODE, Talin, TLN1, TLN2 |
Subjects: | Q Science > QH Natural history > QH301 Biology |
Divisions: | Divisions > Division of Natural Sciences > Biosciences |
Depositing User: | Ben Goult |
Date Deposited: | 28 Oct 2021 19:01 UTC |
Last Modified: | 14 Nov 2022 23:13 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/91148 (The current URI for this page, for reference purposes) |
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