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Genetic variability of indels in the prolactin and dopamine receptor D2 genes and their association with the yield of allanto-amniotic fluid in Russian White laying hens

Dementieva, Natalia V., Fedorova, Elena S., Krutikova, A A, Mitrofanova, Olga V., Stanishevskaya, Olga I., Pleshanov, Nikolai V., Smaragdov, M.G., Kudinov, Andrei A., Terletsky, Valeriy P., Romanov, Michael N. and others. (2020) Genetic variability of indels in the prolactin and dopamine receptor D2 genes and their association with the yield of allanto-amniotic fluid in Russian White laying hens. Tarım Bilimleri Dergisi: Journal of Agricultural Sciences, 26 (3). pp. 373-379. ISSN 2148-9297. (doi:10.15832/ankutbd.483561) (KAR id:89259)

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https://doi.org/10.15832/ankutbd.483561

Abstract

Currently, there is virtually no information on genetic factors affecting the yield of allanto amniotic fluid, which is the raw material for the production of human and animal vaccines. Association studies including this trait are beneficial for increasing productivity of a biotechnological line of chickens used for the production of ‘Clean Eggs’. We examined here a population of the Russian White breed for the effects of indels in the prolactin (PRL) and dopamine receptor D2 (DRD2) genes on the yield of extraembryonic fluid (YEF) and embryo weight at 12.5 days of development. A 24-bp insertion in the 5' flanking region of the PRL gene significantly (P<0.01) increases YEF in the embryos. The heterozygous embryos contained the highest YEF (9.6 mL) than that of the homozygous insertion (9.4 mL) and deletion embryos (8.4 mL). We also found a significant association (P<0.001) between the PRL genotypes and egg weight (EW). The results of the present study suggest a significant association between the PRL gene variation and quantitative traits in the Russian White chickens, contributing to a long-term programme on the effective use of the genetic potential of Russian gene pool breeds and populations of chickens.

Item Type: Article
DOI/Identification number: 10.15832/ankutbd.483561
Projects: [UNSPECIFIED] Development of the Methodology of Genomic Selection for the Conservation and Effective Use of the Potential of Genetic Resources, and Creation of Highly Productive Strains in the Poultry Industry of Russia
Uncontrolled keywords: Chicken population; Biotechnological line; Candidate genes; Insertion-deletion polymorphism; Economically important traits
Subjects: Q Science > QH Natural history > QH426 Genetics
S Agriculture > SF Animal culture
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Signature Themes: Food Systems, Natural Resources and Environment
Depositing User: Mike Romanov
Date Deposited: 14 Jul 2021 11:48 UTC
Last Modified: 21 Jul 2021 13:58 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/89259 (The current URI for this page, for reference purposes)
Dementieva, Natalia V.: https://orcid.org/0000-0003-0210-9344
Fedorova, Elena S.: https://orcid.org/0000-0002-1618-6271
Krutikova, A A: https://orcid.org/0000-0003-2561-145X
Mitrofanova, Olga V.: https://orcid.org/0000-0003-4702-2736
Stanishevskaya, Olga I.: https://orcid.org/0000-0001-9504-3916
Pleshanov, Nikolai V.: https://orcid.org/0000-0002-4634-7515
Smaragdov, M.G.: https://orcid.org/0000-0002-5087-6444
Kudinov, Andrei A.: https://orcid.org/0000-0002-7811-576X
Terletsky, Valeriy P.: https://orcid.org/0000-0003-4043-3823
Romanov, Michael N.: https://orcid.org/0000-0003-3584-4644
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