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Neuronal SKN-1B Modulates Nutritional Signalling Pathways and Mitochondrial Networks to Control Satiety

Tataridas-Pallas, Nikolaos, Thompson, Maximilian A., Howard, Alexander, Brown, Ian, Ezcurra, Marina, Wu, Ziyun, Gonçalves Silva, Isabel, Saunter, Christopher D., Kuerten, Timo, Weinkove, David, and others. (2021) Neuronal SKN-1B Modulates Nutritional Signalling Pathways and Mitochondrial Networks to Control Satiety. PLoS Genetics, . ISSN 1553-7404. E-ISSN 1553-7404. (doi:10.1371/journal.pgen.1009358) (KAR id:88584)

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https://doi.org/10.1371/journal.pgen.1009358

Abstract

The feeling of hunger or satiety results from integration of the sensory nervous system with other physiological and metabolic cues. This regulates food intake, maintains homeostasis and prevents disease. In C. elegans, chemosensory neurons sense food and relay information to the rest of the animal via hormones to control food-related behaviour and physiology. Here we identify a new component of this system, SKN-1B which acts as a central food-responsive node, ultimately controlling satiety and metabolic homeostasis. SKN-1B, an ortholog of mammalian NF-E2 related transcription factors (Nrfs), has previously been implicated with metabolism, respiration and the increased lifespan incurred by dietary restriction. Here we show that SKN-1B acts in two hypothalamus-like ASI neurons to sense food, communicate nutritional status to the organism, and control satiety and exploratory behaviours. This is achieved by SKN-1B modulating endocrine signalling pathways (IIS and TGF-β), and by promoting a robust mitochondrial network. Our data suggest a food-sensing and satiety role for mammalian Nrf proteins.

Item Type: Article
DOI/Identification number: 10.1371/journal.pgen.1009358
Uncontrolled keywords: mitochondria; animal behaviour; food; RNA interface; neurons; sensory perception; escherichia coli
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Jennifer Tullet
Date Deposited: 07 Jun 2021 10:53 UTC
Last Modified: 08 Jun 2021 08:19 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/88584 (The current URI for this page, for reference purposes)
Thompson, Maximilian A.: https://orcid.org/0000-0003-1349-4735
Howard, Alexander: https://orcid.org/0000-0002-0710-9741
Brown, Ian: https://orcid.org/0000-0002-6989-4474
Ezcurra, Marina: https://orcid.org/0000-0003-2739-6984
Gonçalves Silva, Isabel: https://orcid.org/0000-0002-5224-2357
Kuerten, Timo: https://orcid.org/0000-0002-8541-838X
Tullet, Jennifer M.A.: https://orcid.org/0000-0002-2037-526X
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