Desulphurisation of unsymmetrical disulphides tervalent phosphorus nucleophiles

This thesis reports the study of the preparation of symmetrical and unsymmetrical dlsulphldes and their desulphurlsatlon with tervalent phosphorus compounds. The reaction products, klnetlcs, mechanlsm have been Investigated. The Introduction (Chapter one) contains the background to this project with brief reviews on nucleophilic attack by P(III) compounds on a variety of nucleophilic centres and functional groups. These Include saturated carbon, unsaturated carbon, carbonyl carbon, saturated oxygen, nltrogen, halogen and sulphur (II). Chapter two Is divided Into six sections. The first gives a brief review on the purpose and objective of the this thesis. Section two Investigates the best analytical technique employed to monitor reaction mechanlsm, klnetlcs and reaction products. Section three Illustrates the problems associated with the preparation of unsymmetrical dlsulphldes while section four details the products obtained from the desulphurlsatlon reaction In various media. Section five and six report a comparison In desulphurlsatlon kinetics between cyclic and acyclic amlnophosphlne reagents. Chapter three discusses In details three physical methods monitoring reaction pathway(CIDNP) ,reaction mechanism and klnetlcs(HPLC) ,and reaction products In various solvent systems(MC-LC). Chapter four has full experimental procedures. Chapter five lists the references.