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A Novel 3D Printed Hollow Microneedle Microelectromechanical System for Controlled, Personalised Transdermal Drug Delivery

Economidou, Sophia N., Uddin, Md. Jasim, Marques, M.J., Douroumis, Dennis, Sow, Wan Ting, Li, Huaqiong, Reid, Andrew, Windmill, James F. C., Podoleanu, Adrian G.H. (2021) A Novel 3D Printed Hollow Microneedle Microelectromechanical System for Controlled, Personalised Transdermal Drug Delivery. Additive Manufacturing, 38 . Article Number 101815. ISSN 2214-8604. (doi:10.1016/j.addma.2020.101815) (KAR id:85319)

Abstract

The advancement of drug delivery devices is critical for the individualization of patient treatment and the improvement of healthcare. Here, we introduce the 3DMNMEMS, a novel device that combines 3D printing, microneedles (MNs) and Microelectromechanical Systems (MEMS), allowing versatile and controllable by the user transdermal drug delivery. Hollow MNs were designed and 3D printed using Stereolithography, followed by integrating into a MEMS. By employing advanced imaging techniques, we monitored the distribution of liquid delivered by the device within skin tissue in real-time. In vivo testing revealed that the delivery of insulin using the 3DMNMEMS achieved improved glycemic control to diabetic animals compared to subcutaneous injections. These results demonstrated the potential of the 3DMNMEMS as a universal transdermal drug delivery system for personalized care.

Item Type: Article
DOI/Identification number: 10.1016/j.addma.2020.101815
Subjects: Q Science > QC Physics > QC355 Optics
R Medicine > RS Pharmacy and materia medica
T Technology > TA Engineering (General). Civil engineering (General) > TA1520 Applied optics. Photonics
T Technology > TA Engineering (General). Civil engineering (General) > TA401 Materials engineering and construction
T Technology > TJ Mechanical engineering and machinery
Divisions: Divisions > Division of Natural Sciences > Physics and Astronomy
Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Manuel Marques
Date Deposited: 05 Jan 2021 10:19 UTC
Last Modified: 30 Dec 2021 00:00 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/85319 (The current URI for this page, for reference purposes)

University of Kent Author Information

Economidou, Sophia N..

Creator's ORCID:
CReDIT Contributor Roles:

Marques, M.J..

Creator's ORCID: https://orcid.org/0000-0002-7509-0704
CReDIT Contributor Roles:

Podoleanu, Adrian G.H..

Creator's ORCID: https://orcid.org/0000-0002-4899-9656
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