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Discovery of epi-Enprioline as a Novel Drug for the Treatment of Vincristine Resistant Neuroblastoma

Sime, Wondossen, Jemaà, Mohamed, Abassi, Yasmin, Lasorsa, Vito Alessandro, Bonne Køhler, Julie, Hansson, Karin, Bexell, Daniel, Michaelis, Martin, Cinatl, Jindrich, Strand, Daniel, and others. (2020) Discovery of epi-Enprioline as a Novel Drug for the Treatment of Vincristine Resistant Neuroblastoma. International Journal of Molecular Sciences, 21 (18). Article Number 6577. ISSN 1661-6596. E-ISSN 1422-0067. (doi:10.3390/ijms21186577) (KAR id:83142)

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Neuroblastoma is a childhood solid tumour originating from undifferentiated neural progenitor cells of the sympathetic nervous system. Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. In the present study, we aimed to identify novel drugs that can inhibit the growth and survival of chemoresistant neuroblastoma. High-throughput screening identified a small molecule, epi-enprioline that was able to induce apoptosis of vincristine-resistant neuroblastoma cells via the mitochondrial apoptotic pathway. Epi-enprioline reduced tumour growth in multiple

treatment of vincristine-resistant neuroblastoma uncovering a novel strategy, which can be further explored as a treatment for drug-resistant neuroblastoma.

Item Type: Article
DOI/Identification number: 10.3390/ijms21186577
Uncontrolled keywords: chemoresistance; neuroblastoma; epi-enprioline; apoptosis; vincristine
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Depositing User: Martin Michaelis
Date Deposited: 26 Sep 2020 17:17 UTC
Last Modified: 28 Sep 2020 09:35 UTC
Resource URI: (The current URI for this page, for reference purposes)
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