Sime, Wondossen, Jemaà, Mohamed, Abassi, Yasmin, Lasorsa, Vito Alessandro, Bonne Køhler, Julie, Hansson, Karin, Bexell, Daniel, Michaelis, Martin, Cinatl, Jindrich, Strand, Daniel, and others. (2020) Discovery of epi-Enprioline as a Novel Drug for the Treatment of Vincristine Resistant Neuroblastoma. International Journal of Molecular Sciences, 21 (18). Article Number 6577. ISSN 1661-6596. E-ISSN 1422-0067. (doi:10.3390/ijms21186577) (KAR id:83142)
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| Official URL: https://dx.doi.org/10.3390/ijms21186577 |
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Abstract
Neuroblastoma is a childhood solid tumour originating from undifferentiated neural progenitor cells of the sympathetic nervous system. Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. In the present study, we aimed to identify novel drugs that can inhibit the growth and survival of chemoresistant neuroblastoma. High-throughput screening identified a small molecule, epi-enprioline that was able to induce apoptosis of vincristine-resistant neuroblastoma cells via the mitochondrial apoptotic pathway. Epi-enprioline reduced tumour growth in multiple
preclinical models, including an orthotopic neuroblastoma patient-derived xenograft model in vivo. In summary, our data suggest that epi-enprioline can be considered as a lead compound for the
treatment of vincristine-resistant neuroblastoma uncovering a novel strategy, which can be further explored as a treatment for drug-resistant neuroblastoma.
| Item Type: | Article |
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| DOI/Identification number: | 10.3390/ijms21186577 |
| Uncontrolled keywords: | chemoresistance; neuroblastoma; epi-enprioline; apoptosis; vincristine |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Divisions > Division of Natural Sciences > Biosciences |
| Depositing User: | Martin Michaelis |
| Date Deposited: | 26 Sep 2020 17:17 UTC |
| Last Modified: | 05 Nov 2024 12:49 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/83142 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Michaelis, Martin.
| Creator's ORCID: |
 https://orcid.org/0000-0002-5710-5888
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