Ward, Jane L., Wu, Yanqi, Harflett, Claudia, Onafuye, Hannah, Corol, Delia, Lomax, Charlotte, Macalpine, William J., Cinatl Jr., Jindrich, Wass, Mark N., Michaelis, Martin, and others. (2020) Miyabeacin: A new cyclodimer presents a potential role for willow in cancer therapy. Scientific Reports, 10 . E-ISSN 2045-2322. (doi:10.1038/s41598-020-63349-1) (KAR id:81106)
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| Official URL: https://doi.org/10.1038/s41598-020-63349-1 |
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Abstract
Willow (Salix spp.) is well known as a source of medicinal compounds, the most famous being salicin, the progenitor of aspirin. Here we describe the isolation, structure determination, and anti-cancer activity of a cyclodimeric salicinoid (miyabeacin) from S. miyabeana and S. dasyclados. We also show that the capability to produce such dimers is a heritable trait and how variation in structures of natural miyabeacin analogues is derived via cross-over Diels-Alder reactions from pools of ortho-quinol precursors. These transient ortho-quinols have a role in the, as yet uncharacterised, biosynthetic pathways around salicortin, the major salicinoid of many willow genotypes.
| Item Type: | Article |
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| DOI/Identification number: | 10.1038/s41598-020-63349-1 |
| Uncontrolled keywords: | Secondary metabolism; solution-state NMR |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Divisions > Division of Natural Sciences > Biosciences |
| Depositing User: | Martin Michaelis |
| Date Deposited: | 04 May 2020 10:36 UTC |
| Last Modified: | 05 Nov 2024 12:46 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/81106 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Wass, Mark N..
| Creator's ORCID: |
 https://orcid.org/0000-0001-5428-6479
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| CReDIT Contributor Roles: |
Michaelis, Martin.
| Creator's ORCID: |
https://orcid.org/0000-0002-5710-5888
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| CReDIT Contributor Roles: |
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